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    narH nitrate reductase A subunit beta [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945780, updated on 17-Dec-2024

    Summary

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    Official Symbol
    narH
    Official Full Name
    nitrate reductase A subunit beta
    Primary source
    ECOCYC:EG10639
    Locus tag
    b1225
    See related
    ASAP:ABE-0004121
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    chlC; ECK1219
    Summary
    Induced by anaerobiosis plus nitrate. [More information is available at EcoGene: EG10639]. The subunit is the electron transfer subunit containing the iron-sulfur clusters, one [3Fe-4S] cluster and three [4Fe-4S] clusters . [More information is available at EcoCyc: EG10639].
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    Genomic context

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    Sequence:
    NC_000913.3 (1283604..1285142)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator NarL Neighboring gene sensor histidine kinase NarX Neighboring gene nitrate:nitrite antiporter NarK Neighboring gene ncRNA Neighboring gene nitrate reductase A subunit alpha Neighboring gene nitrate reductase 1 molybdenum cofactor assembly chaperone Neighboring gene nitrate reductase A subunit gamma Neighboring gene putative uncharacterized protein YchS

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetics of membrane-bound nitrate reductase A from Escherichia coli with analogues of physiological electron donors--different reaction sites for menadiol and duroquinol. Giordani R, et al. Eur J Biochem, 1997 Dec 1. PMID 9428711
    2. Complete coordination of the four Fe-S centers of the beta subunit from Escherichia coli nitrate reductase. Physiological, biochemical, and EPR characterization of site-directed mutants lacking the highest or lowest potential [4Fe-4S] clusters. Guigliarelli B, et al. Biochemistry, 1996 Apr 16. PMID 8664273
    3. The iron-sulfur cluster composition of Escherichia coli nitrate reductase. Johnson MK, et al. J Biol Chem, 1985 May 10. PMID 2985594
    4. Cardiolipin-based respiratory complex activation in bacteria. Arias-Cartin R, et al. Proc Natl Acad Sci U S A, 2011 May 10. PMID 21518899, Free PMC Article
    5. chlC (nar) operon of Escherichia coli includes structural genes for alpha and beta subunits of nitrate reductase. Edwards ES, et al. J Bacteriol, 1983 Mar. PMID 6298188, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the role of the FS0 cluster of Escherichia coli nitrate reductase A (NarGHI) in enzyme maturation
      Title: Protein crystallography reveals a role for the FS0 cluster of Escherichia coli nitrate reductase A (NarGHI) in enzyme maturation.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Roles of the narJ and narI gene products in the expression of nitrate reductase in Escherichia coli.
    3. molecular characterization of a quinol binding and oxidation site (Q-site) in NarGHI
      Title: Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrate reductase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrate reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within anaerobic respiration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nitrate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nitrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nitrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NarGHI complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NarGHI complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nitrate reductase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nitrate reductase A subunit beta
    NP_415743.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1283604..1285142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415743.1 nitrate reductase A subunit beta [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415743.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1JA46, A0A2X1QHU3, A0A6C9QI37, W1X1G4
      Conserved Domains (1) summary
      COG1140
      Location:1 → 512
      NarY; Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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