Brap BRCA1 associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Brapprovided by RGD
Official Full Name: BRCA1 associated proteinprovided by RGD
Primary source: RGD:1586551
See related: EnsemblRapid:ENSRNOG00000046497 AllianceGenome:RGD:1586551
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; nuclear localization sequence binding activity; and ubiquitin protein ligase activity. Predicted to be involved in Ras protein signal transduction; negative regulation of signal transduction; and protein ubiquitination. Predicted to act upstream of or within MAPK cascade. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human BRAP (BRCA1 associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 137.5), Kidney (RPKM 117.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (40535232..40561726, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (34874533..34901030, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (40381892..40417764, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression.
Title: BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression.

Submit: New GeneRIF Correction

General gene information

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Markers

BI288042 (e-PCR)
- UniSTS:246108

RH129542 (e-PCR)
- UniSTS:212844

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BRCA1-associated protein

NP_001258123.1

EC 2.3.2.27

XP_038945684.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271194.1 → NP_001258123.1 BRCA1-associated protein

See identical proteins and their annotated locations for NP_001258123.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I5Y120, A0A8I5ZU33, A6J1D1

Related

ENSRNOP00000076998.1, ENSRNOT00000104886.2

Conserved Domains (3) summary

cd00162
Location:262 → 303

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd12718
Location:159 → 242

RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)

pfam02148
Location:316 → 378

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

40535232..40561726 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089756.2 → XP_038945684.1 BRCA1-associated protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZU33, A6J1D2

Conserved Domains (4) summary

COG1196
Location:366 → 559

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd16457
Location:231 → 274

RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins

pfam02148
Location:286 → 348

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cd12718
Location:129 → 212

RRM_BRAP2; RNA recognition motif (RRM) found in BRCA1-associated protein (BRAP2)