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    Hprt1 hypoxanthine phosphoribosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24465, updated on 9-Dec-2024

    Summary

    Symbol
    Hprt1provided by RGD
    Full Name
    hypoxanthine phosphoribosyltransferase 1provided by RGD
    Primary source
    RGD:2826
    See related
    EnsemblRapid:ENSRNOG00000031367 AllianceGenome:RGD:2826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hprt; Hgprtase
    Summary
    Enables hypoxanthine phosphoribosyltransferase activity. Involved in cellular response to insulin stimulus; hypoxanthine metabolic process; and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in HRPT-related hyperuricemia and Lesch-Nyhan syndrome. Orthologous to human HPRT1 (hypoxanthine phosphoribosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 786.1), Adrenal (RPKM 493.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hprt1 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (137655744..137687718)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (132736175..132768149)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (158196640..158228815, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene high-mobility group box 4 like 1 Neighboring gene microRNA mir-450b-1 Neighboring gene microRNA 450a-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC112554

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanine phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanine phosphoribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hypoxanthine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hypoxanthine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hypoxanthine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hypoxanthine phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in AMP salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in GMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in GMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in GMP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in GMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in GMP salvage IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within GMP salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in GMP salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in IMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in IMP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in IMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in IMP salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adenine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in central nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cerebral cortex neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopaminergic neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in grooming behavior IEA
    Inferred from Electronic Annotation
    more info
     
    NOT acts_upstream_of_or_within grooming behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within grooming behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in guanine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in guanine salvage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in guanine salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in guanine salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hypoxanthine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hypoxanthine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within hypoxanthine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hypoxanthine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hypoxanthine salvage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hypoxanthine salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hypoxanthine salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymphocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purine nucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within purine ribonucleoside salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purine ribonucleoside salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to amphetamine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in striatum development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within striatum development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hypoxanthine-guanine phosphoribosyltransferase
    Names
    HGPRT
    hypoxanthine guanine phosphoribosyl transferase 1
    hypoxanthine phosphoribosyl transferase
    NP_036715.1
    XP_038955375.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012583.2NP_036715.1  hypoxanthine-guanine phosphoribosyltransferase

      See identical proteins and their annotated locations for NP_036715.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098629
      UniProtKB/Swiss-Prot
      P27605, P70469, Q4KMC5, Q62926
      UniProtKB/TrEMBL
      A0A8L2QNC2, A6KUK3, A6KUK4
      Related
      ENSRNOP00000043388.5, ENSRNOT00000045153.5
      Conserved Domains (1) summary
      cl00309
      Location:6218
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      137655744..137687718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099447.2XP_038955375.1  hypoxanthine-guanine phosphoribosyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZ79, A0A8L2QU26
      Related
      ENSRNOP00000082017.2, ENSRNOT00000109953.2
      Conserved Domains (1) summary
      cl00309
      Location:13218
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain