Slc2a8 solute carrier family 2 member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc2a8provided by RGD
Official Full Name: solute carrier family 2 member 8provided by RGD
Primary source: RGD:620611
See related: EnsemblRapid:ENSRNOG00000022274 AllianceGenome:RGD:620611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Glut8
Summary: Enables dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and male meiosis I. Located in synaptic vesicle. Orthologous to human SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 115.4), Brain (RPKM 76.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (36672589..36682206, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (16274918..16284536, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (12020227..12029920, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hippocampal mRNA abundance of GLUT8 decreases with age in males and females
Title: Chronic stress modulates regional cerebral glucose transporter expression in an age-specific and sexually-dimorphic manner.
Insulin depletion and hyperglycemia do not regulate the expression of GLUT8 in testes.
Title: Expression and regulation of insulin and the glucose transporter GLUT8 in the testes of diabetic rats.
GLUT8 may serve to transport glucose out of the rough ER into the cytosol and in this manner contribute to glucose homeostasis in hippocampal neurons.
Title: Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus.
GLUT8 is a neuron-specific glucose transporter expressed in excitatory and inhibitory neurons.
Title: GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus.
In cells normally expressing it, GLUT8 was associated with a specific intracellular compartment in which it may play an as-yet-uncharacterized role.
Title: GLUT8 subcellular localization and absence of translocation to the plasma membrane in PC12 cells and hippocampal neurons.
GLUT8 is expressed at a low level in the prepubertal testis and Sertoli cells and does not appear to be under l-triiodothyronine control
Title: Ontogenetic profile and thyroid hormone regulation of type-1 and type-8 glucose transporters in rat Sertoli cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143490 (e-PCR)
- UniSTS:232737

RH129995 (e-PCR)
- UniSTS:213283

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose binding	IEA Inferred from Electronic Annotation more info
enables D-glucose binding	ISO Inferred from Sequence Orthology more info
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables D-glucose transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables dehydroascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fructose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables fructose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fructose transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in D-glucose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in D-glucose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in dehydroascorbic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	IEA Inferred from Electronic Annotation more info
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
involved_in fructose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in fructose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in fructose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in male meiosis I	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 8

Names: GLUT-8; glucose transporter type 8; glucose transporter type X1; solute carrier family 2, (facilitated glucose transporter) member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429585.1 → NP_001416514.1 solute carrier family 2, facilitated glucose transporter member 8 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_001429586.1 → NP_001416515.1 solute carrier family 2, facilitated glucose transporter member 8 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_053494.3 → NP_445946.2 solute carrier family 2, facilitated glucose transporter member 8 isoform 1

See identical proteins and their annotated locations for NP_445946.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q9JJZ1, Q9JMA6

UniProtKB/TrEMBL

A6JUA0

Related

ENSRNOP00000022326.4, ENSRNOT00000022327.5

Conserved Domains (1) summary

cl28910
Location:27 → 470

MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

36672589..36682206 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761779.4 → XP_008760001.1 solute carrier family 2, facilitated glucose transporter member 8 isoform X1

Conserved Domains (2) summary

cd06174
Location:30 → 402

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:29 → 417

Sugar_tr; Sugar (and other) transporter
XM_063284736.1 → XP_063140806.1 solute carrier family 2, facilitated glucose transporter member 8 isoform X2
XM_039105998.2 → XP_038961926.1 solute carrier family 2, facilitated glucose transporter member 8 isoform X3

Conserved Domains (1) summary

cl28910
Location:27 → 290

MFS; Major Facilitator Superfamily
XM_063284738.1 → XP_063140808.1 solute carrier family 2, facilitated glucose transporter member 8 isoform X5
XM_039105999.2 → XP_038961927.1 solute carrier family 2, facilitated glucose transporter member 8 isoform X4

Conserved Domains (1) summary

cl28910
Location:27 → 290

MFS; Major Facilitator Superfamily
XM_063284739.1 → XP_063140809.1 solute carrier family 2, facilitated glucose transporter member 8 isoform X5