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    Ppic peptidylprolyl isomerase C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291463, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppicprovided by RGD
    Official Full Name
    peptidylprolyl isomerase Cprovided by RGD
    Primary source
    RGD:1303221
    See related
    EnsemblRapid:ENSRNOG00000017416 AllianceGenome:RGD:1303221
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human PPIC (peptidylprolyl isomerase C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 700.2), Lung (RPKM 312.9) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Ppic in Genome Data Viewer
    Location:
    18q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (49040690..49053296, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (46842410..46855016, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (48372039..48384645, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 2 Neighboring gene sorting nexin 24 Neighboring gene PR/SET domain 6 Neighboring gene U6 spliceosomal RNA Neighboring gene centrosomal protein 120

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC93799

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclosporin A binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase C
    NP_001004215.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004215.1NP_001004215.1  peptidyl-prolyl cis-trans isomerase C precursor

      Status: PROVISIONAL

      Source sequence(s)
      BC078949
      UniProtKB/TrEMBL
      A0A8I5ZN96, F7FHM1, Q6AYQ9
      Related
      ENSRNOP00000023485.5, ENSRNOT00000023485.6
      Conserved Domains (1) summary
      cd01926
      Location:38197
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      49040690..49053296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)