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    Ppp3ca protein phosphatase 3 catalytic subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24674, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ppp3caprovided by RGD
    Official Full Name
    protein phosphatase 3 catalytic subunit alphaprovided by RGD
    Primary source
    RGD:3382
    See related
    EnsemblRapid:ENSRNOG00000009882 AllianceGenome:RGD:3382
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Calna1
    Summary
    Enables calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of insulin secretion; and protein import into nucleus. Located in slit diaphragm. Part of calcineurin complex. Is active in synapse. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 973.9), Muscle (RPKM 448.2) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp3ca in Genome Data Viewer
    Location:
    2q43
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (227839058..228113560)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (225165981..225440978)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (241909332..242186861)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene B-cell scaffold protein with ankyrin repeats 1 Neighboring gene ribosomal protein L29 like 8 Neighboring gene uncharacterized LOC134485975 Neighboring gene protein kinase C and casein kinase substrate in neurons 3, pseudogene 1 Neighboring gene uncharacterized LOC120100622

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin-dependent protein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin-dependent protein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcineurin-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermis development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within multicellular organismal response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcium ion-dependent exocytosis IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-serine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of activated T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of connective tissue replacement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glomerulus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glomerulus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of saliva secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of saliva secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell proliferation involved in kidney morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell proliferation involved in kidney morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in renal filtration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal filtration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle fiber development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within transition between fast and slow fiber ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of calcineurin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of calcineurin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in slit diaphragm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein phosphatase 3 catalytic subunit alpha
    Names
    CAM-PRP catalytic subunit
    CNA alpha
    Calcineurin subunit A alpha
    calcineurin A alpha
    protein phosphatase 3, catalytic subunit, alpha isozyme
    protein phosphatase-2Ba
    NP_058737.1
    XP_006233425.1
    XP_063137376.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017041.2NP_058737.1  protein phosphatase 3 catalytic subunit alpha

      See identical proteins and their annotated locations for NP_058737.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P63329, Q6LDJ8, Q9WUV7, Q9Z1I5
      UniProtKB/TrEMBL
      A0A8I5Y7T7
      Related
      ENSRNOP00000049674.7, ENSRNOT00000047975.7
      Conserved Domains (1) summary
      cd07416
      Location:41345
      MPP_PP2B; PP2B, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      227839058..228113560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281306.1XP_063137376.1  protein phosphatase 3 catalytic subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7T7
      Related
      ENSRNOP00000104489.1, ENSRNOT00000173700.1
    2. XM_006233363.5XP_006233425.1  protein phosphatase 3 catalytic subunit alpha isoform X2

      See identical proteins and their annotated locations for XP_006233425.1

      UniProtKB/TrEMBL
      A0A8I5Y7T7
      Related
      ENSRNOP00000082751.2, ENSRNOT00000105262.2
      Conserved Domains (1) summary
      cd07416
      Location:41345
      MPP_PP2B; PP2B, metallophosphatase domain