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    Cmpk2 cytidine/uridine monophosphate kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314004, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cmpk2provided by RGD
    Official Full Name
    cytidine/uridine monophosphate kinase 2provided by RGD
    Primary source
    RGD:1305881
    See related
    EnsemblRapid:ENSRNOG00000007690 AllianceGenome:RGD:1305881
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tyki
    Summary
    Enables UMP/dUMP kinase activity and thymidylate kinase activity. Involved in dTDP biosynthetic process and dUDP biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human CMPK2 (cytidine/uridine monophosphate kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 94.5), Lung (RPKM 48.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cmpk2 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (48802150..48813652)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (43073706..43085183)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (45683242..45694824)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479352 Neighboring gene radical S-adenosyl methionine domain containing 2 Neighboring gene uncharacterized LOC108351213 Neighboring gene phosphoglycerate mutase 1, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (d)CMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables (d)CMP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables UMP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables UMP/dUMP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thymidylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thymidylate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dTDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dTDP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dTTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dUDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dUDP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    UMP-CMP kinase 2, mitochondrial
    Names
    cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
    thymidylate kinase family LPS-inducible member
    NP_001101487.1
    XP_063117965.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108017.1NP_001101487.1  UMP-CMP kinase 2, mitochondrial

      See identical proteins and their annotated locations for NP_001101487.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HB00, D3ZC63
      Related
      ENSRNOP00000102136.1, ENSRNOT00000133443.1
      Conserved Domains (1) summary
      cl17190
      Location:225413
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      48802150..48813652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261895.1XP_063117965.1  UMP-CMP kinase 2, mitochondrial isoform X1