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    Atp2b3 ATPase plasma membrane Ca2+ transporting 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29599, updated on 27-Nov-2024

    Summary

    Official Symbol
    Atp2b3provided by RGD
    Official Full Name
    ATPase plasma membrane Ca2+ transporting 3provided by RGD
    Primary source
    RGD:621304
    See related
    EnsemblRapid:ENSRNOG00000061304 AllianceGenome:RGD:621304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pmca3
    Summary
    Enables PDZ domain binding activity. Involved in neural retina development. Located in parallel fiber. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic membrane. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1. Orthologous to human ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 168.3), Adrenal (RPKM 127.6) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Atp2b3 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156367582..156464085)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151216483..151289069)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (157236400..157312028, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene HAUS augmin-like complex, subunit 7 Neighboring gene biglycan Neighboring gene cyclin Q, pseudogene 1 Neighboring gene ribosomal protein L28 like 2 Neighboring gene dual specificity phosphatase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    enables P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in parallel fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    plasma membrane calcium-transporting ATPase 3
    Names
    ATPase, Ca++ transporting, plasma membrane 3
    plasma membrane calcium ATPase
    plasma membrane calcium pump
    NP_579822.1
    XP_008771842.1
    XP_038955468.1
    XP_038955469.1
    XP_038955470.1
    XP_038955471.1
    XP_038955473.1
    XP_038955475.1
    XP_038955477.1
    XP_063135923.1
    XP_063135924.1
    XP_063135925.1
    XP_063135926.1
    XP_063135927.1
    XP_063135928.1
    XP_063135929.1
    XP_063135931.1
    XP_063135932.1
    XP_063135933.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431572.1NP_001418501.1  plasma membrane calcium-transporting ATPase 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2K9Q6
    2. NM_001431573.1NP_001418502.1  plasma membrane calcium-transporting ATPase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
    3. NM_133288.3NP_579822.1  plasma membrane calcium-transporting ATPase 3 isoform 3

      See identical proteins and their annotated locations for NP_579822.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q01489, Q63444, Q64568
      UniProtKB/TrEMBL
      A6KRX9
      Related
      ENSRNOP00000083651.2, ENSRNOT00000098998.2
      Conserved Domains (7) summary
      TIGR01517
      Location:191047
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:164448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:8631041
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51121
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:10861138
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:670789
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:509598
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      156367582..156464085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279857.1XP_063135927.1  plasma membrane calcium-transporting ATPase 3 isoform X13

    2. XM_039099540.2XP_038955468.1  plasma membrane calcium-transporting ATPase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q01489, Q63444, Q64568
      Conserved Domains (2) summary
      TIGR01517
      Location:191142
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11811256
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    3. XM_039099541.2XP_038955469.1  plasma membrane calcium-transporting ATPase 3 isoform X2

      UniProtKB/Swiss-Prot
      Q01489, Q63444, Q64568
      Conserved Domains (2) summary
      TIGR01517
      Location:191128
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11671242
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    4. XM_039099545.2XP_038955473.1  plasma membrane calcium-transporting ATPase 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZTE0
      Conserved Domains (2) summary
      TIGR01517
      Location:191142
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11811195
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    5. XM_039099542.2XP_038955470.1  plasma membrane calcium-transporting ATPase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZTE0
      Conserved Domains (2) summary
      TIGR01517
      Location:191142
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11811227
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    6. XM_039099547.2XP_038955475.1  plasma membrane calcium-transporting ATPase 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZTE0
      Conserved Domains (2) summary
      TIGR01517
      Location:191142
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11811196
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    7. XM_039099549.2XP_038955477.1  plasma membrane calcium-transporting ATPase 3 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZTE0
      Conserved Domains (2) summary
      TIGR01517
      Location:191142
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11811195
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    8. XM_039099543.2XP_038955471.1  plasma membrane calcium-transporting ATPase 3 isoform X4

      UniProtKB/Swiss-Prot
      Q01489, Q63444, Q64568
      Conserved Domains (2) summary
      TIGR01517
      Location:191142
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11811226
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    9. XM_063279853.1XP_063135923.1  plasma membrane calcium-transporting ATPase 3 isoform X5

      Related
      ENSRNOP00000098551.2, ENSRNOT00000120993.2
    10. XM_063279854.1XP_063135924.1  plasma membrane calcium-transporting ATPase 3 isoform X8

      UniProtKB/TrEMBL
      A6KRX8
      Related
      ENSRNOP00000081864.1, ENSRNOT00000115963.2
    11. XM_008773620.4XP_008771842.1  plasma membrane calcium-transporting ATPase 3 isoform X6

      UniProtKB/Swiss-Prot
      Q01489, Q63444, Q64568
      Conserved Domains (7) summary
      TIGR01517
      Location:191047
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:164448
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:8631041
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:51121
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:10861162
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:670789
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:509598
      Cation_ATPase; Cation transport ATPase (P-type)
    12. XM_063279855.1XP_063135925.1  plasma membrane calcium-transporting ATPase 3 isoform X10

    13. XM_063279861.1XP_063135931.1  plasma membrane calcium-transporting ATPase 3 isoform X16

      Related
      ENSRNOP00000071471.3, ENSRNOT00000077979.3
    14. XM_063279858.1XP_063135928.1  plasma membrane calcium-transporting ATPase 3 isoform X14

    15. XM_063279862.1XP_063135932.1  plasma membrane calcium-transporting ATPase 3 isoform X17

      UniProtKB/TrEMBL
      A0A8L2UQ79
    16. XM_063279863.1XP_063135933.1  plasma membrane calcium-transporting ATPase 3 isoform X18

    17. XM_063279856.1XP_063135926.1  plasma membrane calcium-transporting ATPase 3 isoform X12

      Related
      ENSRNOP00000075088.3, ENSRNOT00000078100.3
    18. XM_063279859.1XP_063135929.1  plasma membrane calcium-transporting ATPase 3 isoform X15

      UniProtKB/TrEMBL
      A6KRX9