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    Sptbn1 spectrin, beta, non-erythrocytic 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305614, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sptbn1provided by RGD
    Official Full Name
    spectrin, beta, non-erythrocytic 1provided by RGD
    Primary source
    RGD:727922
    See related
    EnsemblRapid:ENSRNOG00000005434 AllianceGenome:RGD:727922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spnb1; Spnb2
    Summary
    Predicted to enable GTPase binding activity; actin filament binding activity; and ankyrin binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including Golgi to plasma membrane protein transport; central nervous system formation; and positive regulation of interleukin-2 production. Predicted to act upstream of or within regulation of SMAD protein signal transduction. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human SPTBN1 (spectrin beta, non-erythrocytic 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 1795.0), Heart (RPKM 1148.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sptbn1 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (108042629..108217884, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (103841713..104016900, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (114517839..114700199, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit S5, pseudogene 1 Neighboring gene reticulon 4 Neighboring gene EMAP like 6 Neighboring gene uncharacterized LOC134481882 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120096711 Neighboring gene ciliary microtubule inner protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ankyrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in M band ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axolemma ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cuticular plate ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of spectrin IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    spectrin beta chain, non-erythrocytic 1
    Names
    bSPII-
    beta II spectrin-like (short form)
    cytoskeleton protein
    non-erythroid spectrin beta
    short form of beta II spectrin
    spectrin beta 2
    spectrin beta chain, brain 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410274.1NP_001397203.1  spectrin beta chain, non-erythrocytic 1

      Status: VALIDATED

      Source sequence(s)
      AY238344, JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JQC5
      Related
      ENSRNOP00000008210.8, ENSRNOT00000008210.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      108042629..108217884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273289.1XP_063129359.1  spectrin beta chain, non-erythrocytic 1 isoform X1

      UniProtKB/TrEMBL
      A6JQC5
    2. XM_063273290.1XP_063129360.1  spectrin beta chain, non-erythrocytic 1 isoform X1

      UniProtKB/TrEMBL
      A6JQC5
    3. XM_063273292.1XP_063129362.1  spectrin beta chain, non-erythrocytic 1 isoform X1

      UniProtKB/TrEMBL
      A6JQC5
    4. XM_063273291.1XP_063129361.1  spectrin beta chain, non-erythrocytic 1 isoform X1

      UniProtKB/TrEMBL
      A6JQC5
    5. XM_063273294.1XP_063129364.1  spectrin beta chain, non-erythrocytic 1 isoform X2

      Related
      ENSRNOP00000099132.1, ENSRNOT00000136768.1
    6. XM_063273295.1XP_063129365.1  spectrin beta chain, non-erythrocytic 1 isoform X3

      Related
      ENSRNOP00000071233.3, ENSRNOT00000084595.3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013130.1: Suppressed sequence

      Description
      NM_001013130.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.