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    Cybc1 cytochrome b-245 chaperone 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 619574, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cybc1provided by RGD
    Official Full Name
    cytochrome b-245 chaperone 1provided by RGD
    Primary source
    RGD:1562022
    See related
    EnsemblRapid:ENSRNOG00000036666 AllianceGenome:RGD:1562022
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in innate immune response and respiratory burst after phagocytosis. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease 5. Orthologous to human CYBC1 (cytochrome b-245 chaperone 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 232.9), Thymus (RPKM 185.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cybc1 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106997018..107003895, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106498730..106505549, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (110424973..110431792, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 3 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene hexosaminidase D Neighboring gene phosphoglycerate mutase 1, pseudogene 1 Neighboring gene nuclear prelamin A recognition factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in respiratory burst after phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory burst after phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in respiratory burst after phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytochrome b-245 chaperone 1
    Names
    eros
    essential for reactive oxygen species protein
    uncharacterized protein C17orf62 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034959.1NP_001030131.1  cytochrome b-245 chaperone 1

      See identical proteins and their annotated locations for NP_001030131.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079126
      UniProtKB/Swiss-Prot
      Q6AYA6
      UniProtKB/TrEMBL
      A0A8I6ARD7, A6HLN7
      Related
      ENSRNOP00000051805.2, ENSRNOT00000054922.4
      Conserved Domains (1) summary
      pfam15169
      Location:2183
      DUF4564; Domain of unknown function (DUF4564)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106997018..107003895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269795.1XP_063125865.1  cytochrome b-245 chaperone 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYA6
      UniProtKB/TrEMBL
      A6HLN7