Dscaml1 DS cell adhesion molecule-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dscaml1provided by RGD
Official Full Name: DS cell adhesion molecule-like 1provided by RGD
Primary source: RGD:1304887
See related: EnsemblRapid:ENSRNOG00000016502 AllianceGenome:RGD:1304887
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cell-cell adhesion mediator activity and protein homodimerization activity. Predicted to be involved in several processes, including embryonic skeletal system morphogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Predicted to be located in cell surface. Predicted to be active in axon and plasma membrane. Orthologous to human DSCAML1 (DS cell adhesion molecule like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 21.9) and Spleen (RPKM 1.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (54637054..54954042)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (45740298..46057322)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (49733835..50056115)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility.
Title: Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility.
DSCAML1 promotes dendritic self-avoidance in cortical neurons, and that phosphorylation at Y1808 is essential in mediating the effects of DSCAML1.
Title: Tyrosine phosphorylation is essential for DSCAML1 to promote dendrite arborization of mouse cortical neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

D8Got66 (e-PCR)
- UniSTS:112149

d8mgh12 (e-PCR)
- UniSTS:122389

RH138369 (e-PCR)
- UniSTS:220456

D8Rat197 (e-PCR), detects polymorphism
- UniSTS:228264

UNH191 (e-PCR)
- UniSTS:23978

BF390668 (e-PCR)
- UniSTS:249518

BB239540 (e-PCR)
- UniSTS:185788

AF045325 (e-PCR)
- UniSTS:12795

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell adhesion molecule DSCAML1

Names: Down syndrome cell adhesion molecule-like 1; Down syndrome cell adhesion molecule-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108141.1 → NP_001101611.1 cell adhesion molecule DSCAML1

See identical proteins and their annotated locations for NP_001101611.1

Status: PROVISIONAL

Source sequence(s)

CH473975

UniProtKB/TrEMBL

A6J449, D3ZPL7

Related

ENSRNOP00000022476.4, ENSRNOT00000022476.6

Conserved Domains (9) summary

cd00096
Location:673 → 739

Ig; Immunoglobulin domain

cd05734
Location:765 → 843

Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:298 → 359

IGc2; Immunoglobulin C-2 Type

smart00409
Location:101 → 173

IG; Immunoglobulin

smart00410
Location:665 → 744

IG_like; Immunoglobulin like

cd00063
Location:1442 → 1532

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:291 → 369

I-set; Immunoglobulin I-set domain

pfam00041
Location:1151 → 1237

fn3; Fibronectin type III domain

cl11960
Location:861 → 949

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

54637054..54954042

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081433.2 → XP_038937361.2 cell adhesion molecule DSCAML1 isoform X1

UniProtKB/TrEMBL

A0A8I6A722

Related

ENSRNOP00000087336.2, ENSRNOT00000102760.2
XM_039081435.2 → XP_038937363.1 cell adhesion molecule DSCAML1 isoform X2

Conserved Domains (7) summary

cd00063
Location:874 → 964

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:583 → 669

fn3; Fibronectin type III domain

pfam13927
Location:795 → 857

Ig_3; Immunoglobulin domain

cd00096
Location:3 → 7

Ig; Ig strand A' [structural motif]

cd05734
Location:179 → 275

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cd05735
Location:276 → 376

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cl11960
Location:1 → 83

Ig; Immunoglobulin domain