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    Zc3h8 zinc finger CCCH type containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311414, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zc3h8provided by RGD
    Official Full Name
    zinc finger CCCH type containing 8provided by RGD
    Primary source
    RGD:1310458
    See related
    EnsemblRapid:ENSRNOG00000017647 AllianceGenome:RGD:1310458
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zc3hdc8
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of thymocyte apoptotic process; regulation of DNA-templated transcription; and snRNA transcription. Predicted to be located in Cajal body; euchromatin; and histone locus body. Predicted to be part of transcription elongation factor complex. Predicted to be active in nucleus. Orthologous to human ZC3H8 (zinc finger CCCH-type containing 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 59.2), Heart (RPKM 59.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zc3h8 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (136629998..136646998, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (116176779..116193752, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (121471836..121488528, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene fibulin 7 Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1, pseudogene 1 Neighboring gene zinc finger CCCH type containing 6 Neighboring gene vinculin/alpha-catenin family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of thymocyte homeostasis by Fliz1. Hwang ES, et al. Immunology, 2002 Aug. PMID 12153508, Free PMC Article
    2. Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1. Hwang ES, et al. J Immunol, 2002 Jul 1. PMID 12077251
    3. Transcripts of Fliz1, a nuclear zinc finger protein, are expressed in discrete foci of the murine fetal liver. Dahm K, et al. Genomics, 2001 Apr 15. PMID 11318609
    4. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Hu D, et al. Mol Cell, 2013 Aug 22. PMID 23932780, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of thymocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in histone locus body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 8
    Names
    zinc finger CCCH type domain containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012090.1 → NP_001012090.1  zinc finger CCCH domain-containing protein 8

      See identical proteins and their annotated locations for NP_001012090.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079122
      UniProtKB/TrEMBL
      F7FCG9, Q6AYB0
      Conserved Domains (1) summary
      smart00356
      Location:240 → 260
      ZnF_C3H1; zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      136629998..136646998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283754.1 → XP_063139824.1  zinc finger CCCH domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      Q6AYB0
      Related
      ENSRNOP00000023845.7, ENSRNOT00000023845.8

    2. XM_063283755.1 → XP_063139825.1  zinc finger CCCH domain-containing protein 8 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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