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    Suox sulfite oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81805, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Suoxprovided by RGD
    Official Full Name
    sulfite oxidaseprovided by RGD
    Primary source
    RGD:619994
    See related
    EnsemblRapid:ENSRNOG00000005987 AllianceGenome:RGD:619994
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables heme binding activity; molybdopterin cofactor binding activity; and sulfite oxidase activity. Involved in response to nutrient. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Biomarker of steatotic liver disease. Human ortholog(s) of this gene implicated in inherited metabolic disorder and isolated sulfite oxidase deficiency. Orthologous to human SUOX (sulfite oxidase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 42.9), Kidney (RPKM 39.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Suox in Genome Data Viewer
    Location:
    7q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1687666..1691759, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (1103149..1107156, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (3098228..3102179, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene prefoldin subunit 1, pseudogene 1 Neighboring gene ribosomal protein S26 Neighboring gene IKAROS family zinc finger 4 Neighboring gene RAB5B, member RAS oncogene family Neighboring gene uncharacterized LOC120093528 Neighboring gene cyclin dependent kinase 2 Neighboring gene premelanosome protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of ingested sulfite on hippocampus antioxidant enzyme activities in sulfite oxidase competent and deficient rats. Kucukatay V, et al. Int J Neurosci, 2007 Jul. PMID 17613108
    2. Molecular cloning of rat liver sulfite oxidase. Expression of a eukaryotic Mo-pterin-containing enzyme in Escherichia coli. Garrett RM, et al. J Biol Chem, 1994 Jan 7. PMID 8276806
    3. Biosynthesis of sulfite oxidase in rat liver - presence of a large precursor form of the enzyme in cytosol. Ono H, et al. J Biochem, 1982 Jan. PMID 7068556
    4. Transport of the precursor for sulfite oxidase into intermembrane space of liver mitochondria: characterization of import and processing activities. Ono H, et al. J Biochem, 1984 Feb. PMID 6715303
    5. Evidence for participation of the inner membrane in the import of sulfite oxidase into the intermembrane space of liver mitochondria. Ono H, et al. Biochem Biophys Res Commun, 1982 Jul 16. PMID 6181785

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sulfite oxidase gene expression in brain and in other tissues.
      Title: Sulphite oxidase gene expression in human brain and in other human and rat tissues.
    2. Results suggest that hippocampus antioxidant enzymes (defense mechanism against the oxidative challenge) are up-regulated by ingested sulfites in sulfite oxidase competent rats.
      Title: Effect of ingested sulfite on hippocampus antioxidant enzyme activities in sulfite oxidase competent and deficient rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin cofactor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdopterin cofactor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molybdopterin cofactor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfite oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfite oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfite oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to nutrient IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfur compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfite oxidase, mitochondrial
    NP_112389.3
    XP_006240864.1
    XP_006240865.1
    XP_063120370.1
    XP_063120371.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031127.4 → NP_112389.3  sulfite oxidase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_112389.3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q07116, Q6P6W0
      UniProtKB/TrEMBL
      A6KSG5, G3V6R5
      Related
      ENSRNOP00000008018.3, ENSRNOT00000008018.7
      Conserved Domains (3) summary
      PLN00177
      Location:169 → 544
      PLN00177; sulfite oxidase; Provisional
      cd02111
      Location:186 → 544
      eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
      pfam00173
      Location:85 → 161
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1687666..1691759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240802.5 → XP_006240864.1  sulfite oxidase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006240864.1

      UniProtKB/Swiss-Prot
      Q07116, Q6P6W0
      UniProtKB/TrEMBL
      A6KSG5, G3V6R5
      Conserved Domains (3) summary
      PLN00177
      Location:169 → 544
      PLN00177; sulfite oxidase; Provisional
      cd02111
      Location:186 → 544
      eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
      pfam00173
      Location:85 → 161
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    2. XM_006240803.5 → XP_006240865.1  sulfite oxidase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006240865.1

      UniProtKB/Swiss-Prot
      Q07116, Q6P6W0
      UniProtKB/TrEMBL
      A6KSG5, G3V6R5
      Conserved Domains (3) summary
      PLN00177
      Location:169 → 544
      PLN00177; sulfite oxidase; Provisional
      cd02111
      Location:186 → 544
      eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
      pfam00173
      Location:85 → 161
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    3. XM_063264301.1 → XP_063120371.1  sulfite oxidase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6KSG5, G3V6R5

    4. XM_063264300.1 → XP_063120370.1  sulfite oxidase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6KSG5, G3V6R5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07116.2 GenPept UniProtKB/Swiss-Prot:Q07116

    Gene LinkOut

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