Phf19 PHD finger protein 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Phf19provided by RGD
Official Full Name: PHD finger protein 19provided by RGD
Primary source: RGD:1310390
See related: EnsemblRapid:ENSRNOG00000018874 AllianceGenome:RGD:1310390
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity; chromatin binding activity; and methylated histone binding activity. Predicted to be involved in negative regulation of macromolecule biosynthetic process; stem cell differentiation; and stem cell population maintenance. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Orthologous to human PHF19 (PHD finger protein 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 28.2), Spleen (RPKM 18.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (38572766..38604950, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (18175281..18197289, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (13957136..13978283, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.
Title: PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PHD finger protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106570.1 → NP_001100040.1 PHD finger protein 19

See identical proteins and their annotated locations for NP_001100040.1

Status: PROVISIONAL

Source sequence(s)

CH474001

UniProtKB/TrEMBL

A6JUD9, F1M1Y4

Related

ENSRNOP00000025528.5, ENSRNOT00000025528.8

Conserved Domains (4) summary

cd15581
Location:195 → 246

PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)

pfam14061
Location:529 → 576

Mtf2_C; Polycomb-like MTF2 factor 2

cd20451
Location:37 → 93

Tudor_PHF19; Tudor domain found in PHD finger protein1 (PHF19) and similar proteins

cl22851
Location:96 → 148

PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

38572766..38604950 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233971.4 → XP_006234033.1 PHD finger protein 19 isoform X1

See identical proteins and their annotated locations for XP_006234033.1

UniProtKB/TrEMBL

A6JUD9, F1M1Y4

Conserved Domains (4) summary

cd15581
Location:195 → 246

PHD2_PHF19; PHD finger 2 found in PHD finger protein 19 (PHF19)

pfam14061
Location:529 → 576

Mtf2_C; Polycomb-like MTF2 factor 2

cd20451
Location:37 → 93

Tudor_PHF19; Tudor domain found in PHD finger protein1 (PHF19) and similar proteins

cl22851
Location:96 → 148

PHD_SF; PHD finger superfamily
XM_063283522.1 → XP_063139592.1 PHD finger protein 19 isoform X2