Arhgap20 Rho GTPase activating protein 20 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap20provided by RGD
Official Full Name: Rho GTPase activating protein 20provided by RGD
Primary source: RGD:1303160
See related: EnsemblRapid:ENSRNOG00000025624 AllianceGenome:RGD:1303160
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RARhoGAP
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rho protein signal transduction. Orthologous to human ARHGAP20 (Rho GTPase activating protein 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 79.8), Muscle (RPKM 66.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (60970480..61055199)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (52074472..52155739)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (56179581..56264343)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RARhoGAP expression was found in differentiating male germ cells and in the testis, suggesting that it may be involved in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis.
Title: Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells.

Submit: New GeneRIF Correction

General gene information

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Markers

BF404613 (e-PCR)
- UniSTS:247150

D8Rat196 (e-PCR), detects polymorphism
- UniSTS:228263

RH137484 (e-PCR)
- UniSTS:219572

RH138047 (e-PCR)
- UniSTS:220134

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of Rho protein signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho GTPase-activating protein 20

Names: RA and RhoGAP domain-containing protein; RhoGTPase activating protein; rho-type GTPase-activating protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001434330.1 → NP_001421259.1 rho GTPase-activating protein 20 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_001434331.1 → NP_001421260.1 rho GTPase-activating protein 20 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_001434332.1 → NP_001421261.1 rho GTPase-activating protein 20 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_213629.3 → NP_998794.2 rho GTPase-activating protein 20 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6J4H7

Conserved Domains (3) summary

cd04402
Location:326 → 519

RhoGAP_ARHGAP20; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces ...

cd13319
Location:48 → 144

PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain

cd17115
Location:158 → 275

RA_RHG20; Ras-associating (RA) domain found in Rho GTPase-activating protein 20 (RHG20) and similar proteins