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    Aspscr1 ASPSCR1 tether for SLC2A4, UBX domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691026, updated on 3-Dec-2024

    Summary

    Official Symbol
    Aspscr1provided by RGD
    Official Full Name
    ASPSCR1 tether for SLC2A4, UBX domain containingprovided by RGD
    Primary source
    RGD:1588666
    See related
    EnsemblRapid:ENSRNOG00000036678 AllianceGenome:RGD:1588666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in glucose homeostasis; intracellular protein transport; and positive regulation of protein modification process. Predicted to act upstream of or within regulation of D-glucose import. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm; nucleus; and vesicle membrane. Human ortholog(s) of this gene implicated in alveolar soft part sarcoma. Orthologous to human ASPSCR1 (ASPSCR1 tether for SLC2A4, UBX domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 134.1), Liver (RPKM 127.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Aspscr1 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106450600..106488231)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105952215..105990059)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109851407..109889339)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene myeloid-associated differentiation marker-like 2 Neighboring gene NOTUM, palmitoleoyl-protein carboxylesterase Neighboring gene 60S ribosomal protein L36a-like Neighboring gene centromere protein X Neighboring gene leucine rich repeat containing 45

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC187913

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein modification process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tether containing UBX domain for GLUT4
    Names
    ASPSCR1, UBX domain containing tether for SLC2A4
    alveolar soft part sarcoma chromosome region, candidate 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398979.1NP_001385908.1  tether containing UBX domain for GLUT4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A665, A6HLH6
      Related
      ENSRNOP00000088273.2, ENSRNOT00000106844.2
      Conserved Domains (3) summary
      cd16105
      Location:1281
      Ubl_ASPSCR1_like; Ubiquitin-like (Ubl) domain found at the N-terminus of mammalian ASPSCR1 (alveolar soft part sarcoma chromosomal region candidate gene 1 protein), Saccharomyces cerevisie Ubx4p, and similar proteins
      cd16118
      Location:388460
      UBX2_UBXN9; Ubiquitin regulatory domain X (UBX) 2 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins
      cd17075
      Location:90171
      UBX1_UBXN9; Ubiquitin regulatory domain X (UBX) 1 found in UBX domain protein 9 (UBXN9, UBXD9, or ASPSCR1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106450600..106488231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269895.1XP_063125965.1  tether containing UBX domain for GLUT4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZW80
      Related
      ENSRNOP00000086050.2, ENSRNOT00000097054.2