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    Phkb phosphorylase kinase regulatory subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361377, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phkbprovided by RGD
    Official Full Name
    phosphorylase kinase regulatory subunit betaprovided by RGD
    Primary source
    RGD:620186
    See related
    EnsemblRapid:ENSRNOG00000024101 AllianceGenome:RGD:620186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calmodulin binding activity. Involved in protein phosphorylation. Part of phosphorylase kinase complex. Human ortholog(s) of this gene implicated in glycogen storage disease IXb. Orthologous to human PHKB (phosphorylase kinase regulatory subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 843.9), Heart (RPKM 144.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Phkb in Genome Data Viewer
    Location:
    19p11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (37179937..37383979, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (21013719..21210671, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (22031684..22281788, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098533 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene integrin alpha FG-GAP repeat containing 1 Neighboring gene uncharacterized LOC134483303

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The alpha and beta subunits of phosphorylase kinase are homologous: cDNA cloning and primary structure of the beta subunit. Kilimann MW, et al. Proc Natl Acad Sci U S A, 1988 Dec. PMID 3200826, Free PMC Article
    2. Coordinated expression of phosphorylase kinase subunits in regenerating skeletal muscle. Cawley KC, et al. J Biol Chem, 1992 Aug 25. PMID 1512265
    3. Purification of rat liver phosphorylase kinase. Chrisman TD, et al. J Biol Chem, 1982 Sep 25. PMID 6809757
    4. Rat skeletal muscle phosphorylase kinase: turnover and control of isozyme levels in culture. Salsgiver WJ, et al. Am J Physiol, 1986 Mar. PMID 3953807
    5. Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure. Brushia RJ, et al. Front Biosci, 1999 Sep 15. PMID 10487978

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphorylase kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphorylase kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphorylase b kinase regulatory subunit beta
    Names
    phosphorylase kinase beta subunit
    phosphorylase kinase, beta
    NP_001014174.1
    NP_001401861.1
    NP_001401862.1
    NP_001401863.1
    XP_063134180.1
    XP_063134181.1
    XP_063134182.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014152.1 → NP_001014174.1  phosphorylase b kinase regulatory subunit beta isoform 4

      See identical proteins and their annotated locations for NP_001014174.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085909
      UniProtKB/TrEMBL
      A0A8I5Y5Q0, F1LNP9, Q5RKH5
      Conserved Domains (1) summary
      pfam00723
      Location:49 → 349
      Glyco_hydro_15; Glycosyl hydrolases family 15

    2. NM_001414932.1 → NP_001401861.1  phosphorylase b kinase regulatory subunit beta isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5Y5Q0, A0A8J8YFM3
      Related
      ENSRNOP00000074948.1, ENSRNOT00000086187.3

    3. NM_001414933.1 → NP_001401862.1  phosphorylase b kinase regulatory subunit beta isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5Y5Q0
      Related
      ENSRNOP00000076912.2, ENSRNOT00000109870.2

    4. NM_001414934.1 → NP_001401863.1  phosphorylase b kinase regulatory subunit beta isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2K9C8, A6KDC6
      Related
      ENSRNOP00000083595.2, ENSRNOT00000110468.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      37179937..37383979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278111.1 → XP_063134181.1  phosphorylase b kinase regulatory subunit beta isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y5Q0
      Related
      ENSRNOP00000039778.6, ENSRNOT00000049624.6

    2. XM_063278110.1 → XP_063134180.1  phosphorylase b kinase regulatory subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9C8

    3. XM_063278112.1 → XP_063134182.1  phosphorylase b kinase regulatory subunit beta isoform X3

    RNA

    1. XR_010060011.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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