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    St14 ST14 transmembrane serine protease matriptase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114093, updated on 27-Nov-2024

    Summary

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    Official Symbol
    St14provided by RGD
    Official Full Name
    ST14 transmembrane serine protease matriptaseprovided by RGD
    Primary source
    RGD:69288
    See related
    EnsemblRapid:ENSRNOG00000005903 AllianceGenome:RGD:69288
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MT-SP1
    Summary
    Enables serine-type peptidase activity. Involved in protein catabolic process. Located in basolateral plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 107.2), Lung (RPKM 55.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See St14 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (37798994..37839881, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (29540805..29581704, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (32240113..32280813, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene amyloid beta precursor like protein 2 Neighboring gene uncharacterized LOC134480153

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation. Inouye K, et al. J Biochem, 2013 Jan. PMID 23038671, Free PMC Article
    2. A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover. Satomi S, et al. Biochem Biophys Res Commun, 2001 Oct 5. PMID 11573963
    3. Increased expression of matriptase is associated with histopathologic grades of cervical neoplasia. Lee JW, et al. Hum Pathol, 2005 Jun. PMID 16021568
    4. The occurrence of matriptase C-terminal fragments on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells. Tsuzuki S, et al. Biosci Biotechnol Biochem, 2009 Nov. PMID 19897900
    5. The role of asparagine-linked glycosylation site on the catalytic domain of matriptase in its zymogen activation. Miyake Y, et al. Biochim Biophys Acta, 2010 Jan. PMID 19800422

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. investigation of protein structure of matriptase and the structural effects on kinetics of proteolysis and zymogen activation
      Title: Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation.
    2. Identification of the matriptase second CUB domain as the secondary site for interaction with hepatocyte growth factor activator inhibitor type-1.
      Title: Identification of the matriptase second CUB domain as the secondary site for interaction with hepatocyte growth factor activator inhibitor type-1.
    3. It is concluded that N-glycosylation site at Asn772 of matriptase is required for the zymogen activation because it plays an important role in rendering this protease catalytically competent in the cellular environment.
      Title: The role of asparagine-linked glycosylation site on the catalytic domain of matriptase in its zymogen activation.
    4. Matriptase C-terminal fragments containing the catalytic serine protease domain were found to occur on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells transfected with a cDNA encoding the protease.
      Title: The occurrence of matriptase C-terminal fragments on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells.
    5. the activity of this protease was found to depend solely on the catalytic domain
      Title: The activity of a type II transmembrane serine protease, matriptase, is dependent solely on the catalytic domain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within epithelial cell morphogenesis involved in placental branching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of tumorigenicity 14 protein
    Names
    matriptase
    membrane-type serine protease
    suppression of tumorigenicity 14 (colon carcinoma)
    suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
    NP_446087.1
    XP_038936588.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053635.2 → NP_446087.1  suppressor of tumorigenicity 14 protein

      See identical proteins and their annotated locations for NP_446087.1

      Status: PROVISIONAL

      Source sequence(s)
      AB049189
      UniProtKB/TrEMBL
      A0A8I6ARC9, A0A9K3Y7V3, F1LRR7, Q9JJI7
      Related
      ENSRNOP00000009139.5, ENSRNOT00000009139.8
      Conserved Domains (4) summary
      cd00041
      Location:340 → 444
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:525 → 559
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:615 → 852
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:88 → 178
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      37798994..37839881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080660.2 → XP_038936588.1  suppressor of tumorigenicity 14 protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARC9, A0A9K3Y7V3, F1LRR7, Q9JJI7
      Conserved Domains (4) summary
      cd00041
      Location:340 → 444
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:525 → 559
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:615 → 852
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:88 → 178
      SEA; SEA domain
    Nucleotide Protein Strain
    Heading Accession and Version

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