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    Nfatc4 nuclear factor of activated T-cells 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305897, updated on 27-Nov-2024

    Summary

    Symbol
    Nfatc4provided by RGD
    Full Name
    nuclear factor of activated T-cells 4provided by RGD
    Primary source
    RGD:1310749
    See related
    EnsemblRapid:ENSRNOG00000020482 AllianceGenome:RGD:1310749
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NF-AT3; NF-ATc4
    Summary
    Enables DNA-binding transcription factor activity and peroxisome proliferator activated receptor binding activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of synaptic plasticity. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NFATC4 (nuclear factor of activated T cells 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 31.8), Uterus (RPKM 28.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nfatc4 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33256912..33284522)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29286998..29314610)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34493163..34502238)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene leukotriene B4 receptor Neighboring gene adenylate cyclase 4 Neighboring gene receptor-interacting serine-threonine kinase 3 Neighboring gene NYN domain and retroviral integrase containing Neighboring gene cerebellin 3 precursor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in brain-derived neurotrophic factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular respiration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to lithium ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of synapse maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of synapse maturation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vascular associated smooth muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vascular associated smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear factor of activated T-cells, cytoplasmic 4
    Names
    T-cell transcription factor NFAT3
    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107264.1NP_001100734.1  nuclear factor of activated T-cells, cytoplasmic 4

      See identical proteins and their annotated locations for NP_001100734.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474049
      UniProtKB/Swiss-Prot
      A0A0G2K0L1, D3Z9H7
      Related
      ENSRNOP00000027789.4, ENSRNOT00000027789.7
      Conserved Domains (3) summary
      cd07881
      Location:407580
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      PHA03247
      Location:40407
      PHA03247; large tegument protein UL36; Provisional
      cd01178
      Location:585685
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33256912..33284522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093303.2XP_038949231.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform X3

      Conserved Domains (2) summary
      cd07881
      Location:13186
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      cd01178
      Location:191291
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    2. XM_039093302.2XP_038949230.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform X2

      Conserved Domains (3) summary
      cd07881
      Location:337510
      RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
      PHA03247
      Location:48337
      PHA03247; large tegument protein UL36; Provisional
      cd01178
      Location:515615
      IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
    3. XM_063274260.1XP_063130330.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1

      UniProtKB/Swiss-Prot
      A0A0G2K0L1, D3Z9H7
    4. XM_063274258.1XP_063130328.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1

      UniProtKB/Swiss-Prot
      A0A0G2K0L1, D3Z9H7
    5. XM_063274259.1XP_063130329.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1

      UniProtKB/Swiss-Prot
      A0A0G2K0L1, D3Z9H7
    6. XM_063274257.1XP_063130327.1  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1

      UniProtKB/Swiss-Prot
      A0A0G2K0L1, D3Z9H7