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    Foxk2 forkhead box K2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303753, updated on 27-Nov-2024

    Summary

    Official Symbol
    Foxk2provided by RGD
    Official Full Name
    forkhead box K2provided by RGD
    Primary source
    RGD:1305408
    See related
    EnsemblRapid:ENSRNOG00000036663 AllianceGenome:RGD:1305408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including intracellular glucose homeostasis; negative regulation of autophagy; and regulation of DNA-templated transcription. Predicted to be located in mitochondrion and nucleoplasm. Orthologous to human FOXK2 (forkhead box K2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 118.9), Thymus (RPKM 117.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Foxk2 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (107040933..107090860)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106542643..106592569)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (110468905..110518854)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nuclear prelamin A recognition factor Neighboring gene uncharacterized LOC134480920 Neighboring gene WD repeat domain 45B Neighboring gene Rab40b, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107075.1NP_001100545.1  forkhead box protein K2 isoform 2

      See identical proteins and their annotated locations for NP_001100545.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6A5H3, A6HLP0, D3ZY28
      Related
      ENSRNOP00000051802.3, ENSRNOT00000054919.5
      Conserved Domains (1) summary
      pfam00250
      Location:69155
      Forkhead; Forkhead domain
    2. NM_001401861.1NP_001388790.1  forkhead box protein K2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A2D9
      Related
      ENSRNOP00000087268.2, ENSRNOT00000099287.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      107040933..107090860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)