U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    elav embryonic lethal abnormal vision [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31000, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    elavprovided by FlyBase
    Official Full Name
    embryonic lethal abnormal visionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260400
    Locus tag
    Dmel_CG4262
    See related
    AllianceGenome:FB:FBgn0260400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    44C11; 9F8A9; CG4262; dHuR; Dmel\CG4262; EC7; EG:65F1.2; Elav; ElaV; ELav; ELAV; elav-1; elav-2; elav-3; Elav-9F8A9; END1-2; fliJ; l(1)1Be; l(1)EC7; l(1)G0031; l(1)G0319; weg
    Summary
    Enables poly(U) RNA binding activity. Involved in central nervous system development and negative regulation of mRNA 3'-end processing. Located in Cajal body. Is expressed in several structures, including adult doublesex neurons; larval midline neurons; sclerite; sense organ; and sensory neurons. Orthologous to human ELAVL3 (ELAV like RNA binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See elav in Genome Data Viewer
    Location:
    1B7-1B8; 1-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (509235..523226, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (403268..417259, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44891 Neighboring gene antisense RNA:CR44892 Neighboring gene silver Neighboring gene elav noncoding regulatory RNA Neighboring gene arginase Neighboring gene uncharacterized protein Neighboring gene beta amyloid protein precursor-like Neighboring gene mir-4960 stem loop

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular analysis of the locus elav in Drosophila melanogaster: a gene whose embryonic expression is neural specific. Campos AR, et al. EMBO J, 1987 Feb. PMID 3107982, Free PMC Article
    2. Uncoupling cell fate determination from patterned cell division in the Drosophila eye. de Nooij JC, et al. Science, 1995 Nov 10. PMID 7481802
    3. Developmental and physiological analysis of a conditional mutation affecting photoreceptor and optic lobe development in Drosophila melanogaster. Homyk T Jr, et al. J Neurogenet, 1985 Nov. PMID 3935768
    4. Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4. Yi J, et al. PLoS One, 2013. PMID 23382971, Free PMC Article
    5. The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs. Robinow S, et al. Science, 1988 Dec 16. PMID 3144044

    See all (1302) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.
      Title: Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.
    2. The biological characters of Bmelav-like genes in the development of Bombyx mori.
      Title: The biological characters of Bmelav-like genes in the development of Bombyx mori.
    3. ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing.
      Title: ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing.
    4. ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
      Title: ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
    5. The Dscam1 long 3' UTR was found to be required for correct Elav-mediated skipping of exon 19. Elav thus co-regulates APA and alternative splicing to generate specific Dscam1 transcripts that are essential for neural development.
      Title: Elav-Mediated Exon Skipping and Alternative Polyadenylation of the Dscam1 Gene Are Required for Axon Outgrowth.
    6. Ubiquitous Elav has regulatory capacity, since derepressed Elav can stabilize an Elav-responsive sensor. Repression of Elav in non-neural territories is crucial as misexpression here has profoundly adverse consequences.
      Title: Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues.
    7. Paused Pol II promotes recruitment of ELAV to extended genes in Drosophila.
      Title: ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system.
    8. The modulation of Hox RNA processing by ELAV serves to adapt the morphogenesis of the CNS to axial level by regulating Hox expression and consequently activating local programmes of neural differentiation.
      Title: The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system.
    9. Reducing Elav levels significantly suppressed the worniu mutant phenotype.
      Title: The Snail family member Worniu is continuously required in neuroblasts to prevent Elav-induced premature differentiation.
    10. RNA immunoprecipitation assays suggest that ELAV directly binds the proximal polyadenylation signals of many target mRNAs
      Title: ELAV mediates 3' UTR extension in the Drosophila nervous system.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in germ cell development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of mRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of oskar mRNA translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    embryonic lethal abnormal vision
    Names
    CG4262-PA
    CG4262-PB
    CG4262-PC
    CG4262-PD
    elav
    elav-PA
    elav-PB
    elav-PC
    elav-PD
    embryonic lethal abnormal visual system
    embryonic lethal, abnormal vision
    embryonically lethal abnormal vision
    weniger

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      509235..523226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258518.3 → NP_001245447.1  embryonic lethal abnormal vision, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16914, Q7K7L9, Q9V3F6
      UniProtKB/TrEMBL
      M9NFP7
      Conserved Domains (1) summary
      TIGR01661
      Location:146 → 483
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. NM_001014713.4 → NP_001014713.1  embryonic lethal abnormal vision, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16914
      Conserved Domains (1) summary
      TIGR01661
      Location:142 → 479
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    3. NM_001144670.2 → NP_001138142.1  embryonic lethal abnormal vision, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138142.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16914
      Conserved Domains (1) summary
      TIGR01661
      Location:142 → 479
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    4. NM_080294.5 → NP_525033.1  embryonic lethal abnormal vision, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525033.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P16914, Q7K7L9, Q9V3F6
      UniProtKB/TrEMBL
      M9NFP7
      Related
      FBpp0070086
      Conserved Domains (1) summary
      TIGR01661
      Location:146 → 483
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NFP7 M9NFP7
    P16914.1 P16914

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous