Hexim Hexamethylene bisacetamide inducible [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Heximprovided by FlyBase
Official Full Name: Hexamethylene bisacetamide inducibleprovided by FlyBase
Primary source: FLYBASE:FBgn0038251
Locus tag: Dmel_CG3508
See related: AllianceGenome:FB:FBgn0038251
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3508; dHEXIM; Dmel\CG3508; dmHEXIM
Summary: Enables 7SK snRNA binding activity and P-TEFb complex binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of 7SK snRNP. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval salivary gland; imaginal disc; larval brain; and ring gland. Orthologous to several human genes including HEXIM1 (HEXIM P-TEFb complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14659438..14661177)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10485160..10486899)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 7SK snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables 7SK snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables P-TEFb complex binding	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables snRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription elongation by RNA polymerase II	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of 7SK snRNP	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain