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    Cul1 Cullin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cul1provided by FlyBase
    Official Full Name
    Cullin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015509
    Locus tag
    Dmel_CG1877
    See related
    AllianceGenome:FB:FBgn0015509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1877; cul-1; Cul-1; cul1; CUL1; Cullin-1; Cullin1; dCul-1; dCul1; dCUL1; dmCUL1; Dmel\CG1877; l(2)02074; l(2)k01207; lin 19; Lin-19; lin-19/cul-1; lin19; Lin19; lin19-like; Q9V312
    Summary
    Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of neuron remodeling; and positive regulation of protein metabolic process. Located in nucleus. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; germline cell; imaginal disc; and mesoderm. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cul1 in Genome Data Viewer
    Location:
    43F1-43F2; 2-57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7916856..7921579)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3804361..3809084)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Autophagy-related 10 Neighboring gene Diacyl glycerol kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 43b Neighboring gene Lysine demethylase 4A Neighboring gene Major Facilitator Superfamily Transporter 12 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class X

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysregulation of core components of SCF complex in poly-glutamine disorders. Bhutani S, et al. Cell Death Dis, 2012 Nov 22. PMID 23171848, Free PMC Article
    2. The F-Box Protein CG5003 Regulates Axon Pruning and the Integrity of the Drosophila Mushroom Body. Yang M, et al. Front Mol Neurosci, 2021. PMID 33716667, Free PMC Article
    3. Putative Drosophila odor receptor OR43b localizes to dendrites of olfactory neurons. Elmore T, et al. Insect Biochem Mol Biol, 2001 Jun 22. PMID 11378414
    4. COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch. Djagaeva I, et al. PLoS One, 2009 Oct 27. PMID 19859546, Free PMC Article
    5. The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity. Suisse A, et al. Fly (Austin), 2018. PMID 29355077, Free PMC Article

    See all (173) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease.
      Title: CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease.
    2. mutant larvae accumulate high levels of non-neddylated Cul1, suggesting that Int6 is a positive regulator of cullin neddylation
      Title: The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.
    3. Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.
      Title: Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin ligase complex scaffold activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cullin 1
    Names
    CG1877-PA
    CG1877-PB
    CG1877-PC
    CG1877-PD
    Cul1-PA
    Cul1-PB
    Cul1-PC
    Cul1-PD
    SCF-betaTrCP complex
    cullin
    cullin-1
    cullin1
    dCullin
    dCullin1
    lin-19-like
    lin19-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7916856..7921579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165571.2 → NP_724623.1  cullin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724623.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ78, Q0E9G0, Q24311, Q9V312
      UniProtKB/TrEMBL
      D3DMX2
      Related
      FBpp0087921
      Conserved Domains (3) summary
      smart00182
      Location:454 → 593
      CULLIN; Cullin
      smart00884
      Location:701 → 765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 669
      Cullin; Cullin family

    2. NM_165570.3 → NP_724622.1  cullin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ78, Q0E9G0, Q24311, Q9V312
      UniProtKB/TrEMBL
      D3DMX2
      Related
      FBpp0087922
      Conserved Domains (3) summary
      smart00182
      Location:454 → 593
      CULLIN; Cullin
      smart00884
      Location:701 → 765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 669
      Cullin; Cullin family

    3. NM_165569.2 → NP_724621.1  cullin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724621.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ78, Q0E9G0, Q24311, Q9V312
      UniProtKB/TrEMBL
      D3DMX2
      Related
      FBpp0087923
      Conserved Domains (3) summary
      smart00182
      Location:454 → 593
      CULLIN; Cullin
      smart00884
      Location:701 → 765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 669
      Cullin; Cullin family

    4. NM_078931.4 → NP_523655.1  cullin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523655.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ78, Q0E9G0, Q24311, Q9V312
      UniProtKB/TrEMBL
      D3DMX2
      Related
      FBpp0087924
      Conserved Domains (3) summary
      smart00182
      Location:454 → 593
      CULLIN; Cullin
      smart00884
      Location:701 → 765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 669
      Cullin; Cullin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24311.2 Q24311

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