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    Nopp140 Nopp140 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40433, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Nopp140provided by FlyBase
    Official Full Name
    Nopp140provided by FlyBase
    Primary source
    FLYBASE:FBgn0037137
    Locus tag
    Dmel_CG7421
    See related
    AllianceGenome:FB:FBgn0037137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7421; Dmel\CG7421; DmNopp140; NCL; Nopp- 140; nopp140
    Summary
    Involved in rRNA 2'-O-methylation. Located in nucleolus. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; head epidermis primordium; larval muscle cell; and mesoderm. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nopp140 in Genome Data Viewer
    Location:
    78F4-78F4; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21832774..21836685)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21825874..21829785)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene delta-1-Pyrroline-5-carboxylate dehydrogenase 1 Neighboring gene transfer RNA:Cysteine-GCA 4-1 Neighboring gene uncharacterized protein Neighboring gene mushroom-body expressed

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two splice variants of Nopp140 in Drosophila melanogaster. Waggener JM, et al. Mol Biol Cell, 2002 Jan. PMID 11809845, Free PMC Article
    2. R1 retrotransposons in the nucleolar organizers of Drosophila melanogaster are transcribed by RNA polymerase I upon heat shock. Raje HS, et al. Transcription, 2018. PMID 30063880, Free PMC Article
    3. Tracking nucleolar dynamics with GFP-Nopp140 during Drosophila oogenesis and embryogenesis. McCain J, et al. Cell Tissue Res, 2006 Jan. PMID 16158326
    4. The Nopp140 gene in Drosophila melanogaster displays length polymorphisms in its large repetitive second exon. Baral SS, et al. Mol Genet Genomics, 2019 Aug. PMID 31006039
    5. RNAi knockdown of Nopp140 induces Minute-like phenotypes in Drosophila. Cui Z, et al. Mol Biol Cell, 2007 Jun. PMID 17392509, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nopp140 is not required for overall nucleolar integrity, but is required for 2'-O-methylation. Loss of Nopp140 impairs 2'-O-methylation of 18S and 28S rRNA.
      Title: Deletion of Drosophila Nopp140 induces subcellular ribosomopathies.
    2. occurrence of apoptosis, autophagy and phenoloxidase A3 release to the hemolymph upon nucleolar stress correlated well with the demonstrated activation of Jun N-terminal kinase (JNK) in Nopp140-depleted larvae
      Title: Nucleolar stress in Drosophila melanogaster: RNAi-mediated depletion of Nopp140.
    3. Data show that RNAi knockdown of Nopp140 induces Minute-like phenotypes in Drosophila that are reminiscent of human craniofacial malformations associated with Treacher Collins syndrome.
      Title: RNAi knockdown of Nopp140 induces Minute-like phenotypes in Drosophila.
    4. Pole cells contained GFP-Nopp140 during the syncytial embryonic stages, but their nucleologenesis started at gastrulation.
      Title: Tracking nucleolar dynamics with GFP-Nopp140 during Drosophila oogenesis and embryogenesis.
    5. Two splice variants of Nopp140
      Title: Two splice variants of Nopp140 in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in rRNA 2'-O-methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Nopp140
    Names
    CG7421-PA
    CG7421-PB
    CG7421-PE
    CG7421-PF
    Nopp140-PA
    Nopp140-PB
    Nopp140-PE
    Nopp140-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21832774..21836685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275266.1 → NP_001262195.1  Nopp140, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262195.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFZ1, Q7Z2C9

    2. NM_168940.3 → NP_730693.1  Nopp140, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730693.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTV5, Q7Z2C9
      Related
      FBpp0088542
      Conserved Domains (1) summary
      pfam05022
      Location:613 → 678
      SRP40_C; SRP40, C-terminal domain

    3. NM_001202229.2 → NP_001189158.2  Nopp140, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189158.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSM4, Q7Z2C9
      Conserved Domains (1) summary
      pfam05022
      Location:612 → 677
      SRP40_C; SRP40, C-terminal domain

    4. NM_168941.4 → NP_730694.2  Nopp140, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730694.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z2C9, Q9VNX5, Q9VNX6
      Related
      FBpp0089003
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MSM4 M9MSM4
    M9PFZ1 M9PFZ1
    Q7KTV5 Q7KTV5
    Q7Z2C9 Q7Z2C9
    Q95RR9 Q95RR9
    Q9VNX6 Q9VNX6

    Gene LinkOut

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