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    eIF2Bdelta eukaryotic translation initiation factor 2B subunit delta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37706, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF2Bdeltaprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 2B subunit deltaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034858
    Locus tag
    Dmel_CG10315
    See related
    AllianceGenome:FB:FBgn0034858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10315; Dmel\CG10315; eIF2B-delta
    Summary
    Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in several structures, including adult head; embryonic epipharynx; embryonic/larval midgut primordium; gland; and gut section. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See eIF2Bdelta in Genome Data Viewer
    Location:
    59D9-59D10; 2-102 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23386521..23389052)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19274044..19276575)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44784 Neighboring gene uncharacterized protein Neighboring gene reduction of Rh1 Neighboring gene Myotubularin related protein 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster. Williams DD, et al. J Biol Chem, 2001 Feb 9. PMID 11060303
    2. Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR. Vasudevan D, et al. Nat Commun, 2020 Sep 16. PMID 32938929, Free PMC Article
    3. Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. Fan W, et al. PLoS Genet, 2017 Mar. PMID 28273089, Free PMC Article
    4. Extensive use of RNA-binding proteins in Drosophila sensory neuron dendrite morphogenesis. Olesnicky EC, et al. G3 (Bethesda), 2014 Feb 19. PMID 24347626, Free PMC Article
    5. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2B complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2B subunit delta
    Names
    CG10315-PA
    CG10315-PB
    CG10315-PC
    CG10315-PD
    eIF2B-delta
    eIF2Bdelta-PA
    eIF2Bdelta-PB
    eIF2Bdelta-PC
    eIF2Bdelta-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23386521..23389052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137946.4 → NP_611790.1  eukaryotic translation initiation factor 2B subunit delta, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L6, Q9W1Q8
      Related
      FBpp0071923
      Conserved Domains (2) summary
      COG1184
      Location:306 → 619
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:323 → 611
      IF-2B; Initiation factor 2 subunit family

    2. NM_001169794.2 → NP_001163265.1  eukaryotic translation initiation factor 2B subunit delta, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163265.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8X6, Q494L6
      Conserved Domains (2) summary
      COG1184
      Location:256 → 569
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:273 → 561
      IF-2B; Initiation factor 2 subunit family

    3. NM_166602.3 → NP_726321.1  eukaryotic translation initiation factor 2B subunit delta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8X6, Q494L6
      Related
      FBpp0071922
      Conserved Domains (2) summary
      COG1184
      Location:256 → 569
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:273 → 561
      IF-2B; Initiation factor 2 subunit family

    4. NM_166601.2 → NP_726320.1  eukaryotic translation initiation factor 2B subunit delta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8X6, Q494L6
      Related
      FBpp0071924
      Conserved Domains (2) summary
      COG1184
      Location:256 → 569
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
      pfam01008
      Location:273 → 561
      IF-2B; Initiation factor 2 subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8X6 Q0E8X6
    Q8MPP1 Q8MPP1
    Q9W1Q8 Q9W1Q8

    Gene LinkOut

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