fdl fused lobes [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fdlprovided by FlyBase
Official Full Name: fused lobesprovided by FlyBase
Primary source: FLYBASE:FBgn0045063
Locus tag: Dmel_CG8824
See related: AllianceGenome:FB:FBgn0045063
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8824; Dmel\CG8824; Fdl; FDL; l(2)k17040
Summary: Enables beta-N-acetylglucosaminidase activity. Involved in N-glycan processing; brain development; and rhodopsin biosynthetic process. Located in late endosome and plasma membrane. Colocalizes with Golgi apparatus and endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in Sandhoff disease; Tay-Sachs disease; and spinal muscular atrophy. Orthologous to human HEXA (hexosaminidase subunit alpha) and HEXB (hexosaminidase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 49A9-49A10; 2-67 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12487451..12507333, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8374956..8394838, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results demonstrated that the processing fdl protein genes had been successfully isolated from Trichoplusia ni and Bombyx mori.
Title: Identification of genes encoding N-glycan processing beta-N-acetylglucosaminidases in Trichoplusia ni and Bombyx mori: Implications for glycoengineering of baculovirus expression systems.
the fdl gene encodes a novel hexosaminidase responsible for the occurrence of paucimannosidic N-glycans in Drosophila
Title: The Drosophila fused lobes gene encodes an N-acetylglucosaminidase involved in N-glycan processing.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables beta-N-acetylgalactosaminidase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-N-acetylglucosaminidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-N-acetylglucosaminidase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-N-acetylhexosaminidase activity	IEA Inferred from Electronic Annotation more info
enables beta-N-acetylhexosaminidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in N-glycan processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
NOT involved_in chitin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycosaminoglycan metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhodopsin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fused lobes

Names: CG8824-PB; CG8824-PC; CG8824-PE; CG8824-PF; CG8824-PG; beta-N-acetylglucosaminidase; fdl-PB; fdl-PC; fdl-PE; fdl-PF; fdl-PG

NP_001286350.1

EC 3.2.1.-

EC 3.2.1.52

NP_001286351.1

EC 3.2.1.-

EC 3.2.1.52

NP_001356962.1

EC 3.2.1.-

EC 3.2.1.52

NP_725178.2

EC 3.2.1.-

EC 3.2.1.52

NP_725179.1

EC 3.2.1.-

EC 3.2.1.52

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

12487451..12507333 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299421.1 → NP_001286350.1 fused lobes, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286350.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MZ16, Q8WSF3, Q95RY8, Q9V6C8

UniProtKB/TrEMBL

A0A0B4LF89, A9UN21

Conserved Domains (2) summary

cd06562
Location:276 → 641

GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...

pfam14845
Location:97 → 252

Glycohydro_20b2; beta-acetyl hexosaminidase like
NM_001299422.1 → NP_001286351.1 fused lobes, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286351.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LG91, A9UN21

Conserved Domains (2) summary

cd06562
Location:288 → 653

GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...

pfam14845
Location:109 → 264

Glycohydro_20b2; beta-acetyl hexosaminidase like
NM_001370052.1 → NP_001356962.1 fused lobes, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4P7VJW3, A9UN21

Conserved Domains (2) summary

cd06562
Location:276 → 641

GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...

pfam14845
Location:97 → 252

Glycohydro_20b2; beta-acetyl hexosaminidase like
NM_165909.3 → NP_725179.1 fused lobes, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725179.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MZ16, Q8WSF3, Q95RY8, Q9V6C8

UniProtKB/TrEMBL

A0A0B4LF89, A9UN21

Related

FBpp0087057

Conserved Domains (2) summary

cd06562
Location:276 → 641

GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...

pfam14845
Location:97 → 252

Glycohydro_20b2; beta-acetyl hexosaminidase like
NM_165908.2 → NP_725178.2 fused lobes, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725178.2

Status: REVIEWED

UniProtKB/TrEMBL

A9UN21

Related

FBpp0087058

Conserved Domains (2) summary

cd06562
Location:289 → 654

GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...

pfam14845
Location:110 → 265

Glycohydro_20b2; beta-acetyl hexosaminidase like