Arl2 ADP ribosylation factor-like 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Arl2provided by FlyBase
Official Full Name: ADP ribosylation factor-like 2provided by FlyBase
Primary source: FLYBASE:FBgn0004908
Locus tag: Dmel_CG7435
See related: AllianceGenome:FB:FBgn0004908
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Arf; Arf84D; Arf84F; arl2; ARL2; Arl84F; CG 7435; CG7435; Dm Arf84F; Dmel\CG7435; Q06849
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in establishment of mitotic spindle orientation and establishment or maintenance of neuroblast polarity. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in adult head; embryonic/larval gut; and larval brain. Orthologous to human ARL2 (ARF like GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8341100..8341872)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4166822..4167594)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISM Inferred from Sequence Model more info	PubMed
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of neuroblast polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization involved in mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	TAS Traceable Author Statement more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info