enok enoki mushroom [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: enokprovided by FlyBase
Official Full Name: enoki mushroomprovided by FlyBase
Primary source: FLYBASE:FBgn0034975
Locus tag: Dmel_CG11290
See related: AllianceGenome:FB:FBgn0034975
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-60Ba; anon-WO0200864.1; anon-WO0200864.2; Cg11290; CG11290; Dmel\CG11290; dmHAG406; Enok; KAT6; rot; S1
Summary: Enables histone H3K23 acetyltransferase activity. Involved in several processes, including female germ-line stem cell population maintenance; nervous system development; and positive regulation of DNA-templated transcription. Part of MOZ/MORF histone acetyltransferase complex. Is expressed in spermatozoon; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in several diseases, including Arboleda-Tham syndrome; Ohdo syndrome, SBBYS variant; acute myeloid leukemia; bipolar disorder; and leiomyoma. Orthologous to several human genes including KAT6B (lysine acetyltransferase 6B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 60B10-60B10; 2-106 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24099210..24107032)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19986733..19994555)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
Title: Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription.
Title: Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription.
Enok counteracts Polycomb group proteins-mediated repression and influences the ability of trithorax group proteins to maintain transcription of its target genes.
Title: Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator.
Enok-mediated H3K23 acetylation (H3K23Ac) promotes the expression of spir, providing a specific mechanism linking oocyte polarization to histone modification.
Title: Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire.
Enok is required for maintaining GSCs non-autonomously.
Title: The Drosophila putative histone acetyltransferase Enok maintains female germline stem cells through regulating Bruno and the niche.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K23 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of piRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MOZ/MORF histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: enoki mushroom

Names: CG11290-PA; CG11290-PB; enok-PA; enok-PB; rotkehlchen

NP_001286823.1

EC 2.3.1.48

NP_523838.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24099210..24107032

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299894.1 → NP_001286823.1 enoki mushroom, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286823.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W1A9

Conserved Domains (6) summary

pfam09528
Location:1150 → 1539

Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)

smart00249
Location:248 → 292

PHD; PHD zinc finger

pfam01853
Location:768 → 947

MOZ_SAS; MOZ/SAS family

cl00073
Location:95 → 152

H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

cl17182
Location:713 → 989

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

cl22851
Location:183 → 215

PHD_SF; PHD finger superfamily
NM_079114.2 → NP_523838.1 enoki mushroom, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523838.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W1A9

Related

FBpp0072159

Conserved Domains (6) summary

pfam09528
Location:1150 → 1539

Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)

smart00249
Location:248 → 292

PHD; PHD zinc finger

pfam01853
Location:768 → 947

MOZ_SAS; MOZ/SAS family

cl00073
Location:95 → 152

H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

cl17182
Location:713 → 989

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

cl22851
Location:183 → 215

PHD_SF; PHD finger superfamily