CBP sarcoplasmic calcium-binding protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CBPprovided by FlyBase
Official Full Name: sarcoplasmic calcium-binding proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0026144
Locus tag: Dmel_CG1435
See related: AllianceGenome:FB:FBgn0026144
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA.GH12350; BcDNA:GH12350; cbp; CG1435; dCBP; Dmel\CG1435
Summary: Predicted to enable calcium ion binding activity. Involved in defense response to Gram-negative bacterium. Located in cytosol and nucleoplasm. Is expressed in several structures, including antennal anlage; antennal primordium; central brain anlage; head epidermis primordium; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 7B2-7B2; 1-20 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (7337352..7342731)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (7231385..7236764)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity.
Title: CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity.
Psn regulates CBP levels in the adult fly brain in a manner that is independent of Notch signaling
Title: Presenilin controls CBP levels in the adult Drosophila central nervous system.
Data suggest that trithorax (TRX)-dependent acetylation of H3K27 by CBP prevents H3K27me3 at Polycomb target genes and constitutes a key part of the molecular mechanism by which TRX antagonizes or prevents Polycomb silencing.
Title: CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in nucleoplasm	HDA more info	PubMed

General protein information

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Preferred Names: sarcoplasmic calcium-binding protein

Names: CBP-PA; CBP-PB; CBP-PC; CG1435-PA; CG1435-PB; CG1435-PC; Ca2+ - binding protein; calcium binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

7337352..7342731

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078515.4 → NP_511070.1 sarcoplasmic calcium-binding protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511070.1

Status: REVIEWED

UniProtKB/TrEMBL

O96676

Related

FBpp0071011

Conserved Domains (2) summary

cd00051
Location:220 → 273

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:219 → 273

EF-hand_7; EF-hand domain pair
NM_001272380.2 → NP_001259309.1 sarcoplasmic calcium-binding protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259309.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHB8

Conserved Domains (2) summary

cd00051
Location:220 → 273

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:219 → 273

EF-hand_7; EF-hand domain pair
NM_206638.3 → NP_996361.1 sarcoplasmic calcium-binding protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996361.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KVU4

Conserved Domains (1) summary

cd00051
Location:153 → 206

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...