chico chico [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: chicoprovided by FlyBase
Official Full Name: chicoprovided by FlyBase
Primary source: FLYBASE:FBgn0024248
Locus tag: Dmel_CG5686
See related: AllianceGenome:FB:FBgn0024248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0078940.1; anon-WO0078940.4; BcDNA.GH11263; BcDNA:GH11263; CG5686; chic; Chico; CHICO; Chico/IRS; dIRS; Dmel\CG5686; fs(2)4; fs(2)ry4; IRS; IRS/chico
Summary: Enables insulin receptor binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of cell communication; and spermatogenesis. Located in cell cortex and cytosol. Is expressed in Kenyon cell and adult brain. Used to study amnestic disorder; glucose metabolism disease; intellectual disability; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; congenital nongoitrous hypothyroidism 9; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1); IRS2 (insulin receptor substrate 2); and IRS4 (insulin receptor substrate 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 31B1-31B1; 2-40 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10242512..10247078, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10242512..10247078, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that the insulin receptor substrate gene chico controls the functioning of the systems of metabolism of dopamine and juvenile hormone in Drosophila melanogaster females under normal conditions and in thermal stress
Title: Mutation in the Drosophila insulin-like receptor substrate, chico, affects the neuroendocrine stress-reaction development.
Mutations in chico reduce expression of the rutabaga-type adenylyl cyclase (rut), leading to decreased cAMP synthesis in the mushroom bodies.
Title: Learning defects in Drosophila growth restricted chico mutants are caused by attenuated adenylyl cyclase activity.
longevity assurance mutants of chico, the Drosophila insulin receptor substrate homolog, require Drosophila d4eBP to slow aging.
Title: Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP.
Expressing chico(+)in the mushroom bodies(MB) restores the number of MB neurons to wild-type amounts and also rescues chico learning defects.
Title: Mutations in the Drosophila insulin receptor substrate, CHICO, impair olfactory associative learning.
chico acts with the transcription factor FOXO to extend Drosophila lifespan
Title: Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan.
Lnk acts in parallel to Chico downstream of the insulin receptor to regulate cellular growth.
Title: The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway.
results demonstrate that chico1 induces a state equivalent to submaximal, dietary restriction-induced slowing of aging
Title: Dietary restriction in long-lived dwarf flies.
Mortality deceleration is a phenotype of chico.
Title: The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico.
chico(1) ovaries transplanted into wild-type females did not undergo vitellogenesis indicating that CHICO is necessary in the ovary for vitellogenic maturation.
Title: Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary.
Genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased sensitivity to the intoxicating effects of ethanol.
Title: Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SH2 domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables insulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	IGI Inferred from Genetic Interaction more info	PubMed
enables insulin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables insulin-like growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol 3-kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol 3-kinase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth of a germarium-derived egg chamber	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of entry into reproductive diapause	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary spermatocyte growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to anoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitellogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chico

Names: CG5686-PA; CG5686-PB; CG5686-PC; chico-PA; chico-PB; chico-PC; flipper; insulin receptor substrate; insulin-like receptor substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10242512..10247078 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001201843.2 → NP_001188772.1 chico, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188772.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D0UY43, D0UY45, D0UY46, D0UY47, D0UY49, D0UY50, D0UY51, D0UY52, D0UY54, D0UY55, D0UY61, D0UY62, D0UY64, D0UY65, D0UY66, D0UY67, D0UY68, Q5U0V5, Q9U4G2, Q9XTN2

UniProtKB/TrEMBL

H1ZYH1, M9PCQ8

Conserved Domains (3) summary

cd01204
Location:122 → 235

PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)

cd01257
Location:7 → 112

PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

pfam00169
Location:25 → 104

PH; PH domain
NM_164899.3 → NP_723540.1 chico, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723540.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D0UY43, D0UY45, D0UY46, D0UY47, D0UY49, D0UY50, D0UY51, D0UY52, D0UY54, D0UY55, D0UY61, D0UY62, D0UY64, D0UY65, D0UY66, D0UY67, D0UY68, Q5U0V5, Q9U4G2, Q9XTN2

UniProtKB/TrEMBL

H1ZYH1, M9PCQ8

Related

FBpp0079677

Conserved Domains (3) summary

cd01204
Location:122 → 235

PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)

cd01257
Location:7 → 112

PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

pfam00169
Location:25 → 104

PH; PH domain
NM_001273387.1 → NP_001260316.1 chico, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260316.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D0UY43, D0UY45, D0UY46, D0UY47, D0UY49, D0UY50, D0UY51, D0UY52, D0UY54, D0UY55, D0UY61, D0UY62, D0UY64, D0UY65, D0UY66, D0UY67, D0UY68, Q5U0V5, Q9U4G2, Q9XTN2

UniProtKB/TrEMBL

H1ZYH1, M9PCQ8

Conserved Domains (3) summary

cd01204
Location:122 → 235

PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)

cd01257
Location:7 → 112

PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

pfam00169
Location:25 → 104

PH; PH domain