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    eIF2alpha eukaryotic translation initiation factor 2 subunit alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF2alphaprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 2 subunit alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261609
    Locus tag
    Dmel_CG9946
    See related
    AllianceGenome:FB:FBgn0261609
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9946; deIF2alpha; Dmel\CG9946; eIF-2; eIF-2 a; eIF-2 alpha; eiF-2alpha; eIF-2alpha; EIF-2alpha; eIF-2alphaeIF-2alpha; eIF2 alpha; eIF2-alpha; eIF2a; Eif2alpha; EIF2alpha; Elf; elF2alpha; IF2A_DROME; l(1)14Cf; l(1)19-153; M(1)14C; M(1)19-153; M(1)8e3-10; P-eIF2alpha
    Summary
    Enables translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 2 complex; and eukaryotic translation initiation factor 2B complex. Is expressed in adult head; adult heart; and ovary. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF2alpha in Genome Data Viewer
    Location:
    14C6-14C6; 1-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16445176..16446993, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16339209..16341026, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene hangover Neighboring gene Cell division cycle 50 Neighboring gene rings lost Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 4H1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the Drosophila melanogaster eIF-2 alpha gene encoding the alpha subunit of translation initiation factor eIF-2. Qu S, et al. Gene, 1994 Mar 25. PMID 8144032
    2. PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila. Elvira R, et al. Int J Mol Sci, 2020 Jan 28. PMID 32013014, Free PMC Article
    3. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α. Ochi N, et al. PLoS Genet, 2021 Dec. PMID 34871307, Free PMC Article
    4. Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase. Pomar N, et al. Eur J Biochem, 2003 Jan. PMID 12605680
    5. Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster. Williams DD, et al. J Biol Chem, 2001 Feb 9. PMID 11060303

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2alpha.
      Title: Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α.
    2. PERK-Mediated eIF2alpha Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila.
      Title: PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila.
    3. Therapeutic modulation of eIF2alpha phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.
      Title: Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of eukaryotic 48S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2B complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 subunit alpha
    Names
    CG9946-PA
    CG9946-PB
    eIF-2alpha
    eIF2alpha-PA
    eIF2alpha-PB
    eukaryotic initiation factor 2alpha
    eukaryotic translation initiation factor 2
    eukaryotic translation initiation factor 2alpha
    minute (1) 14C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16445176..16446993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298400.1 → NP_001285329.1  eukaryotic translation initiation factor 2 subunit alpha, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285329.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41374, Q9V3G2
      UniProtKB/TrEMBL
      X2JFR6
      Conserved Domains (3) summary
      COG1093
      Location:6 → 278
      SUI2; Translation initiation factor 2, alpha subunit (eIF-2alpha) [Translation, ribosomal structure and biogenesis]
      cd04452
      Location:13 → 88
      S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
      pfam07541
      Location:130 → 239
      EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit

    2. NM_132902.4 → NP_573130.1  eukaryotic translation initiation factor 2 subunit alpha, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573130.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41374, Q9V3G2
      UniProtKB/TrEMBL
      X2JFR6
      Related
      FBpp0074075
      Conserved Domains (3) summary
      COG1093
      Location:6 → 278
      SUI2; Translation initiation factor 2, alpha subunit (eIF-2alpha) [Translation, ribosomal structure and biogenesis]
      cd04452
      Location:13 → 88
      S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
      pfam07541
      Location:130 → 239
      EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41374.1 P41374
    X2JFR6 X2JFR6

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