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    CG3529 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39093, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3529provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035995
    Locus tag
    Dmel_CG3529
    See related
    AllianceGenome:FB:FBgn0035995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3529; DmTOM1
    Summary
    Predicted to enable clathrin binding activity. Predicted to be involved in signal transduction. Predicted to be active in endosome and membrane. Is expressed in several structures, including adult head; embryonic anal pad; embryonic/larval midgut primordium; ganglia; and gut section. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including TOM1L2 (target of myb1 like 2 membrane trafficking protein) and TOM1 (target of myb1 membrane trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3529 in Genome Data Viewer
    Location:
    67B7-67B7; 3-29 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9446864..9450785)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9439964..9443885)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Blocked early in transport 3 Neighboring gene Nuclear factor Y-box A Neighboring gene Sting-regulated gene 3 Neighboring gene uncharacterized protein Neighboring gene ghiberti Neighboring gene pleiohomeotic like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploring the ESCRTing machinery in eukaryotes. Winter V, et al. Trends Plant Sci, 2006 Mar. PMID 16488176, Free PMC Article
    2. Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. Finan D, et al. Proc Natl Acad Sci U S A, 2011 Apr 5. PMID 21368190, Free PMC Article
    3. Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster. Hurd TR, et al. Dev Cell, 2016 Dec 5. PMID 27923120, Free PMC Article
    4. An anti-inflammatory transcriptional cascade conserved from flies to humans. Pavlidaki A, et al. Cell Rep, 2022 Oct 18. PMID 36261018
    5. In vivo Profiling of the Alk Proximitome in the Developing Drosophila Brain. Uçkun E, et al. J Mol Biol, 2021 Nov 19. PMID 34624297

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3529-PB
    CG3529-PC
    CG3529-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9446864..9450785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140058.3 → NP_648315.1  uncharacterized protein Dmel_CG3529, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648315.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U57, Q9VSZ1
      Related
      FBpp0076189
      Conserved Domains (2) summary
      cd03565
      Location:17 → 158
      VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
      cd14233
      Location:222 → 307
      GAT_TOM1_like; GAT domain found in target of myb protein 1 (Tom1) protein family

    2. NM_001274700.1 → NP_001261629.1  uncharacterized protein Dmel_CG3529, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261629.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF36
      Conserved Domains (2) summary
      cd03565
      Location:17 → 158
      VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
      cd14233
      Location:222 → 307
      GAT_TOM1_like; GAT domain found in target of myb protein 1 (Tom1) protein family

    3. NM_001274701.1 → NP_001261630.1  uncharacterized protein Dmel_CG3529, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261630.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEX2
      Conserved Domains (2) summary
      cd03565
      Location:17 → 158
      VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
      cd14233
      Location:222 → 307
      GAT_TOM1_like; GAT domain found in target of myb protein 1 (Tom1) protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEX2 M9PEX2
    M9PF36 M9PF36
    Q9VSZ1 Q9VSZ1

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