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    Naprt Nicotinate phosphoribosyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naprtprovided by FlyBase
    Official Full Name
    Nicotinate phosphoribosyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031589
    Locus tag
    Dmel_CG3714
    See related
    AllianceGenome:FB:FBgn0031589
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF51037; CG3714; Dmel\CG3714
    Summary
    Predicted to enable nicotinate phosphoribosyltransferase activity. Predicted to be involved in NAD salvage and response to oxidative stress. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Orthologous to human NAPRT (nicotinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naprt in Genome Data Viewer
    Location:
    24D8-24D8; 2-11 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4189340..4198071, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4189340..4198071, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lectin-24Db Neighboring gene Tubulin-binding cofactor C Neighboring gene fat Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual treatment with kynurenine pathway inhibitors and NAD(+) precursors synergistically extends life span in Drosophila. Gabrawy MM, et al. Aging Cell, 2024 Apr. PMID 38481042, Free PMC Article
    2. Reconstructing eukaryotic NAD metabolism. Rongvaux A, et al. Bioessays, 2003 Jul. PMID 12815723
    3. Heritable shifts in redox metabolites during mitochondrial quiescence reprogramme progeny metabolism. Hocaoglu H, et al. Nat Metab, 2021 Sep. PMID 34545253, Free PMC Article
    4. The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila. Llobet Rosell A, et al. Elife, 2022 Dec 23. PMID 36476387, Free PMC Article
    5. Genome-wide analysis of nuclear mRNA export pathways in Drosophila. Herold A, et al. EMBO J, 2003 May 15. PMID 12743041, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nicotinate phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nicotinate phosphoribosyltransferase
    Names
    CG3714-PA
    CG3714-PB
    CG3714-PC
    CG3714-PD
    CG3714-PE
    CG3714-PF
    CG3714-PG
    CG3714-PH
    CG3714-PI
    Naprt-PA
    Naprt-PB
    Naprt-PC
    Naprt-PD
    Naprt-PE
    Naprt-PF
    Naprt-PG
    Naprt-PH
    Naprt-PI
    NP_001097077.1
    NP_001260015.1
    NP_001260016.1
    NP_001400993.1
    NP_608818.4
    NP_722961.1
    NP_722962.1
    NP_722963.1
    NP_722964.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4189340..4198071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273086.1 → NP_001260015.1  nicotinate phosphoribosyltransferase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC31
      Conserved Domains (1) summary
      PLN02885
      Location:22 → 550
      PLN02885; nicotinate phosphoribosyltransferase

    2. NM_164575.2 → NP_722964.1  nicotinate phosphoribosyltransferase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722964.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQX4
      Related
      FBpp0077172
      Conserved Domains (2) summary
      PLN02885
      Location:22 → 667
      PLN02885; nicotinate phosphoribosyltransferase
      cd01570
      Location:27 → 521
      NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...

    3. NM_164573.2 → NP_722962.1  nicotinate phosphoribosyltransferase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722962.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQX4
      Related
      FBpp0077168
      Conserved Domains (2) summary
      PLN02885
      Location:22 → 667
      PLN02885; nicotinate phosphoribosyltransferase
      cd01570
      Location:27 → 521
      NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...

    4. NM_164574.2 → NP_722963.1  nicotinate phosphoribosyltransferase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722963.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQX4
      Related
      FBpp0077169
      Conserved Domains (2) summary
      PLN02885
      Location:22 → 667
      PLN02885; nicotinate phosphoribosyltransferase
      cd01570
      Location:27 → 521
      NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...

    5. NM_001273087.1 → NP_001260016.1  nicotinate phosphoribosyltransferase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260016.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEF6
      Conserved Domains (2) summary
      PLN02885
      Location:22 → 662
      PLN02885; nicotinate phosphoribosyltransferase
      cd01570
      Location:27 → 516
      NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...

    6. NM_001103607.2 → NP_001097077.1  nicotinate phosphoribosyltransferase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097077.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQX4
      Conserved Domains (2) summary
      PLN02885
      Location:22 → 667
      PLN02885; nicotinate phosphoribosyltransferase
      cd01570
      Location:27 → 521
      NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...

    7. NM_164572.2 → NP_722961.1  nicotinate phosphoribosyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722961.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRQ7, Q9VQX4
      Related
      FBpp0077170
      Conserved Domains (1) summary
      PLN02885
      Location:22 → 555
      PLN02885; nicotinate phosphoribosyltransferase

    8. NM_134974.5 → NP_608818.4  nicotinate phosphoribosyltransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608818.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQX4
      Related
      FBpp0077171
      Conserved Domains (2) summary
      PLN02885
      Location:22 → 667
      PLN02885; nicotinate phosphoribosyltransferase
      cd01570
      Location:27 → 521
      NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...

    9. NM_001414090.1 → NP_001400993.1  nicotinate phosphoribosyltransferase, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0X1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC31 M9PC31
    M9PEF6 M9PEF6
    Q9VQX4.2 Q9VQX4

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