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    Teh3 tipE homolog 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50170, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Teh3provided by FlyBase
    Official Full Name
    tipE homolog 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0040697
    Locus tag
    Dmel_CG18676
    See related
    AllianceGenome:FB:FBgn0040697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18676; Dmel\CG18676; TEH1; TEH3
    Summary
    Enables sodium channel regulator activity. Involved in regulation of sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Teh3 in Genome Data Viewer
    Location:
    64A10-64A10; 3-10 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4182645..4184663, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4182645..4184663, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Endoplasmic reticulum oxidoreductin-1-like Neighboring gene uncharacterized protein Neighboring gene tipE homolog 4 Neighboring gene tipE homolog 2 Neighboring gene Vacuolar H[+] ATPase M9.7 subunit c Neighboring gene temperature-induced paralytic E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants. Wang L, et al. Insect Biochem Mol Biol, 2015 May. PMID 25744892
    2. A remarkably stable TipE gene cluster: evolution of insect Para sodium channel auxiliary subunits. Li J, et al. BMC Evol Biol, 2011 Nov 18. PMID 22098672, Free PMC Article
    3. Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE. Derst C, et al. Biochem Biophys Res Commun, 2006 Jan 20. PMID 16325765
    4. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
    5. Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. Abruzzi KC, et al. Genes Dev, 2011 Nov 15. PMID 22085964, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. inhibited the sodium current decay and increased the persistent current of three DmNav variants
      Title: Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tipE homolog 3
    Names
    CG18676-PA
    Teh3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4182645..4184663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144078.2 → NP_652335.1  tipE homolog 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652335.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPH5, Q9VZG8
      Related
      FBpp0073113
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZG8 Q9VZG8

    Gene LinkOut

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