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    MBD-R2 MBD-R2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41498, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MBD-R2provided by FlyBase
    Official Full Name
    MBD-R2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038016
    Locus tag
    Dmel_CG10042
    See related
    AllianceGenome:FB:FBgn0038016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10042; CG17393; Dm Tam3; dMBD-R2; Dmel\CG10042; MBD; mbd-R2; MBD-R2/NSL; Mbdr2; MBDR2; Mbrd2; TAM3
    Summary
    Enables promoter-specific chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in euchromatin; nucleus; and polytene chromosome interband. Part of NSL complex. Is expressed in organism and spermatozoon. Orthologous to human PHF20 (PHD finger protein 20) and PHF20L1 (PHD finger protein 20 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MBD-R2 in Genome Data Viewer
    Location:
    87B7-87B8; 3-52 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12352143..12356265, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8177865..8181987, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 419 Neighboring gene Tim17a1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila. Gupta T, et al. Sci Rep, 2017 Jul 14. PMID 28710457, Free PMC Article
    2. Functional conservation of MBD proteins: MeCP2 and Drosophila MBD proteins alter sleep. Gupta T, et al. Genes Brain Behav, 2016 Nov. PMID 27489246, Free PMC Article
    3. Now you see it: genome methylation makes a comeback in Drosophila. Boffelli D, et al. Bioessays, 2014 Dec. PMID 25220261
    4. The NSL complex regulates housekeeping genes in Drosophila. Lam KC, et al. PLoS Genet, 2012. PMID 22723752, Free PMC Article
    5. An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Meunier S, et al. Nat Commun, 2015 Aug 5. PMID 26243146, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MBD-R2
    Names
    CG10042-PB
    MBD-R2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12352143..12356265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169461.3 → NP_731688.2  MBD-R2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731688.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGA4
      UniProtKB/TrEMBL
      Q7KSN0
      Related
      FBpp0082081
      Conserved Domains (4) summary
      cd04508
      Location:292 → 329
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd01396
      Location:449 → 522
      MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
      pfam05485
      Location:4 → 86
      THAP; THAP domain
      cl22851
      Location:919 → 963
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KSN0 Q7KSN0
    Q9VGA4 Q9VGA4

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