Tctp Translationally controlled tumor protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tctpprovided by FlyBase
Official Full Name: Translationally controlled tumor proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0037874
Locus tag: Dmel_CG4800
See related: AllianceGenome:FB:FBgn0037874
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4800; Dmel\CG4800; dTCTP; TCTP
Summary: Enables guanyl-nucleotide exchange factor activity and protein kinase activator activity. Involved in several processes, including cellular response to gamma radiation; mitotic DNA damage checkpoint signaling; and positive regulation of cell size. Located in nucleus and polytene chromosome. Is expressed in adult head and adult heart. Orthologous to several human genes including TPT1P8 (TPT1 pseudogene 8) and TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 86D8-86D8; 3-50 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11210247..11211898)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7035969..7037004)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
Title: Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
Topoisomerase II is regulated by translationally controlled tumor protein for cell survival during organ growth in Drosophila.
Title: Topoisomerase II is regulated by translationally controlled tumor protein for cell survival during organ growth in Drosophila.
Regulation of epithelial integrity and organ growth by Tctp and Coracle in Drosophila.
Title: Regulation of epithelial integrity and organ growth by Tctp and Coracle in Drosophila.
REVIEW: Tctp functions in Drosophila and discuss their implications in cancer
Title: Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosophila Studies.
TCTP may promote the progression of epithelial ovarian cancer and reduce the sensitiveness of HO8910 cells to cisplatin.
Title: Expression and clinical role of TCTP in epithelial ovarian cancer.
TCTP has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster
Title: TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster.
plant AtTCTP can fully rescue cell proliferation defects in Drosophila loss of function for dTCTP
Title: Translationally controlled tumor protein is a conserved mitotic growth integrator in animals and plants.
Drosophila TCTP (dTCTP) displays GEF activity to Rheb and is essential for Rheb activation in organ growth
Title: To cease or to proliferate: new insights into TCTP function from a Drosophila study.
Our studies identify TCTP as a direct regulator of Rheb and a potential therapeutic target for tuberous sclerosis disease.
Title: Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G2 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic intra-S DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: translationally controlled tumor protein

Names: CG4800-PA; CG4800-PB; Tctp-PA; Tctp-PB; translationally controlled tumor protein ortholog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

11210247..11211898

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001316502.1 → NP_001303431.1 translationally controlled tumor protein, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q49UC2, Q95TW0, Q9VGS2

UniProtKB/TrEMBL

A0A126GUT1, S5PU30

Conserved Domains (1) summary

pfam00838
Location:1 → 167

TCTP; Translationally controlled tumor protein
NM_141791.3 → NP_650048.1 translationally controlled tumor protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650048.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q49UC2, Q95TW0, Q9VGS2

UniProtKB/TrEMBL

A0A126GUT1, S5PU30

Related

FBpp0081820

Conserved Domains (1) summary

pfam00838
Location:1 → 167

TCTP; Translationally controlled tumor protein