trbl tribbles [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: trblprovided by FlyBase
Official Full Name: tribblesprovided by FlyBase
Primary source: FLYBASE:FBgn0028978
Locus tag: Dmel_CG5408
See related: AllianceGenome:FB:FBgn0028978
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5408; Dmel\CG5408; trb; Trbl
Summary: Enables protein kinase inhibitor activity. Involved in several processes, including negative regulation of mitotic nuclear division; negative regulation of signal transduction; and positive regulation of cell size. Located in cytosol and nucleus. Is expressed in several structures, including antennal anlage; antennal primordium; central brain anlage; follicle cell; and head epidermis primordium. Used to study glucose metabolism disease. Orthologous to human TRIB1 (tribbles pseudokinase 1); TRIB2 (tribbles pseudokinase 2); and TRIB3 (tribbles pseudokinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 77C1-77C1; 3-47 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20396288..20401609, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20389388..20394709, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Tribbles decreases body weight and increases sleep duration.
Title: Upregulation of Tribbles decreases body weight and increases sleep duration.
Sima, a Drosophila homolog of HIF-1alpha, in fat body tissue inhibits larval body growth by inducing Tribbles gene expression.
Title: Sima, a Drosophila homolog of HIF-1α, in fat body tissue inhibits larval body growth by inducing Tribbles gene expression.
Results identify trbl as a direct bantam target gene that mediates its growth regulatory role and oncogenic function. trbl downregulation in the wing disc accelerates G2/M progression in the cell cycle.
Title: The miRNA bantam regulates growth and tumorigenesis by repressing the cell cycle regulator tribbles.
Study shows that drosophila melanogaster tribbles pseudokinase is essential for proper memory formation. Expression analysis shows that the tribble protein is expressed widely in the fly brain.
Title: The Drosophila melanogaster tribbles pseudokinase is necessary for proper memory formation.
The results indicate that high-fat diet-induced Gbb signaling provokes insulin resistance by increasing tribbles expression.
Title: High fat diet-induced TGF-β/Gbb signaling provokes insulin resistance through the tribbles expression.
these data show that Drosophila Trbl has a conserved role to bind Akt and block Akt-mediated insulin signaling, and implicate Trib proteins as novel sites of signaling pathway integration that link nutrient availability with cell growth and proliferation
Title: Drosophila tribbles antagonizes insulin signaling-mediated growth and metabolism via interactions with Akt kinase.
Trbl is expressed at high levels in the nuclei of follicle cell epithelia and is downregulated in delaminating epithelia as expression of Slbo (C/EBP) is upregulated.
Title: The kinase domain of Drosophila Tribbles is required for turnover of fly C/EBP during cell migration.
SKIP3, an ortholog of this protein, is overexpressed in human tumors and is regulated by hypoxia.
Title: SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral furrow formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tribbles

Names: CG5408-PA; trbl-PA; tribble; tribbless

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

20396288..20401609 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079933.4 → NP_524672.1 tribbles [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524672.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3Z1

Related

FBpp0077893

Conserved Domains (1) summary

cl21453
Location:131 → 397

PKc_like; Protein Kinases, catalytic domain