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    roq roquin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39818, updated on 9-Dec-2024

    Summary

    Official Symbol
    roqprovided by FlyBase
    Official Full Name
    roquinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036621
    Locus tag
    Dmel_CG16807
    See related
    AllianceGenome:FB:FBgn0036621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16807; Dmel\CG16807; NEST:bs21b12; Roq
    Summary
    Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytoplasmic stress granule. Is expressed in several structures, including dorsal epidermis primordium; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and embryonic/larval salivary gland. Orthologous to human RC3H1 (ring finger and CCCH-type domains 1) and RC3H2 (ring finger and CCCH-type domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See roq in Genome Data Viewer
    Location:
    72E3-72E4; 3-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16370938..16378566, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16364038..16371666, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 72Ec Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 3

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA stem-loop binding  
    enables double-stranded RNA binding  
    enables mRNA binding  
    enables metal ion binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables zinc ion binding PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in protein polyubiquitination  
    involved_in protein polyubiquitination  
    involved_in ubiquitin-dependent protein catabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule PubMed 

    General protein information

    Preferred Names
    roquin
    Names
    CG16807-PA
    CG16807-PB
    CG16807-PC
    roq-PA
    roq-PB
    roq-PC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16370938..16378566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275011.2 → NP_001261940.1  roquin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV48
      Conserved Domains (2) summary
      pfam00642
      Location:418 → 444
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam14634
      Location:13 → 55
      zf-RING_5; zinc-RING finger domain
    2. NM_140629.3 → NP_648886.1  roquin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV48
      Related
      FBpp0075181
      Conserved Domains (2) summary
      pfam00642
      Location:418 → 444
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam14634
      Location:13 → 55
      zf-RING_5; zinc-RING finger domain
    3. NM_001275012.2 → NP_001261941.1  roquin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261941.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VV48
      Conserved Domains (2) summary
      pfam00642
      Location:418 → 444
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam14634
      Location:13 → 55
      zf-RING_5; zinc-RING finger domain
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