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    DptB Diptericin B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37184, updated on 17-Dec-2024

    Summary

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    Official Symbol
    DptBprovided by FlyBase
    Official Full Name
    Diptericin Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034407
    Locus tag
    Dmel_CG10794
    See related
    AllianceGenome:FB:FBgn0034407
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    147473_at; BcDNA:RH29451; CG10794; Dipt; diptB; DiptB; Diptericin; Dmel\CG10794; Dpt; dpt B; dptB; dptlp
    Summary
    Involved in defense response to Gram-positive bacterium; humoral immune response; and response to wounding. Located in extracellular space. Is expressed in embryonic/larval hemolymph. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DptB in Genome Data Viewer
    Location:
    55F8-55F8; 2-86 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18867391..18867895)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14754896..14755400)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Diptericin A Neighboring gene serrano Neighboring gene Vacuolar H[+] ATPase 100kD subunit 3 Neighboring gene proliferation disrupter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemometric Analysis of Bacterial Peptidoglycan Reveals Atypical Modifications That Empower the Cell Wall against Predatory Enzymes and Fly Innate Immunity. Espaillat A, et al. J Am Chem Soc, 2016 Jul 27. PMID 27337563
    2. Diptericin-like protein: an immune response gene regulated by the anti-bacterial gene induction pathway in Drosophila. Lee JH, et al. Gene, 2001 Jun 27. PMID 11418244
    3. The Influence of Cannabinoids on Drosophila Behaviors, Longevity, and Traumatic Injury Responses of the Adult Nervous System. Candib A, et al. Cannabis Cannabinoid Res, 2024 Jun. PMID 37158809,
    4. Identification of Regulatory Host Genes Involved in Sigma Virus Replication Using RNAi Knockdown in Drosophila. Liao JF, et al. Insects, 2019 Oct 11. PMID 31614679, Free PMC Article
    5. Drosophila Exhibit Divergent Sex-Based Responses in Transcription and Motor Function After Traumatic Brain Injury. Shah EJ, et al. Front Neurol, 2020. PMID 32636795, Free PMC Article

    See all (246) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data demonstrate an alphavirus antiviral response involving the Imd and Jak-STAT mediated expression of dptB and attC.
      Title: An antiviral role for antimicrobial peptides during the arthropod response to alphavirus replication.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in humoral immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diptericin B
    Names
    CG10794-PA
    Diptericin-B
    DiptericinB
    DptB-PA
    diptercin B
    diptericin
    diptericin-like protein
    diptericine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18867391..18867895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079063.4 → NP_523787.2  diptericin B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523787.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBF6, Q9BJF1
      Related
      FBpp0085803
      Conserved Domains (1) summary
      pfam03769
      Location:70 → 120
      Attacin_C; Attacin, C-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBF6 A1ZBF6
    Q8IGG1 Q8IGG1
    Q9BJF1 Q9BJF1
    Q9BJF2 Q9BJF2
    Q9GN49 Q9GN49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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