U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cyp49a1 Cytochrome P450 49a1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36105, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cyp49a1provided by FlyBase
    Official Full Name
    Cytochrome P450 49a1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033524
    Locus tag
    Dmel_CG18377
    See related
    AllianceGenome:FB:FBgn0033524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    49a1; CG12894; CG18377; Cyp49A1; Cyp49a1p; Dmel\CG18377
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in several structures, including cercus; embryonic anal pad; embryonic epipharynx; embryonic head; and gut section. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cyp49a1 in Genome Data Viewer
    Location:
    47A7-47A9; 2-62 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10449350..10458892, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6336855..6346397, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ran-binding protein M Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit o Neighboring gene Chromatin assembly factor 1, p105 subunit Neighboring gene uncharacterized protein Neighboring gene withered

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evolution of supergene families associated with insecticide resistance. Ranson H, et al. Science, 2002 Oct 4. PMID 12364796
    2. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Dembeck LM, et al. Elife, 2015 Nov 14. PMID 26568309, Free PMC Article
    3. Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Sathyanarayanan S, et al. Genes Dev, 2008 Jun 1. PMID 18519643, Free PMC Article
    4. Mutations of the withered (whd) gene in Drosophila melanogaster confer hypersensitivity to oxidative stress and are lesions of the carnitine palmitoyltransferase I (CPT I) gene. Strub BR, et al. Genome, 2008 Jun. PMID 18521119
    5. Genome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci. Talsma AD, et al. Mol Brain, 2014 Dec 5. PMID 25476251, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytochrome P450 49a1
    Names
    CG18377-PA
    CG18377-PC
    CG18377-PD
    CG18377-PE
    Cyp49a1-PA
    Cyp49a1-PC
    Cyp49a1-PD
    Cyp49a1-PE
    cytochrome P450
    NP_001246256.1
    NP_610588.2
    NP_724937.1
    NP_995803.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10449350..10458892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136744.4 → NP_610588.2  cytochrome P450 49a1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610588.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZC2, B8A3V2, Q8MZH1, Q8SY18, Q9V5L3
      UniProtKB/TrEMBL
      A0A0B4K7M1
      Related
      FBpp0087403
      Conserved Domains (1) summary
      cl12078
      Location:104 → 565
      p450; Cytochrome P450

    2. NM_001259327.2 → NP_001246256.1  cytochrome P450 49a1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246256.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZC2, B8A3V2, Q8MZH1, Q8SY18, Q9V5L3
      UniProtKB/TrEMBL
      A0A0B4K7M1
      Conserved Domains (1) summary
      cl12078
      Location:104 → 565
      p450; Cytochrome P450

    3. NM_206081.2 → NP_995803.1  cytochrome P450 49a1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995803.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZC2, B8A3V2, Q8MZH1, Q8SY18, Q9V5L3
      UniProtKB/TrEMBL
      A0A0B4K7M1
      Conserved Domains (1) summary
      cl12078
      Location:104 → 565
      p450; Cytochrome P450

    4. NM_165774.3 → NP_724937.1  cytochrome P450 49a1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724937.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V5L3
      Related
      FBpp0087404
      Conserved Domains (1) summary
      cl12078
      Location:33 → 391
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7M1 A0A0B4K7M1
    Q9V5L3.3 Q9V5L3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools