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    alpha-Man-Ia alpha-Mannosidase class I a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha-Man-Iaprovided by FlyBase
    Official Full Name
    alpha-Mannosidase class I aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259170
    Locus tag
    Dmel_CG42275
    See related
    AllianceGenome:FB:FBgn0259170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    a-Man-Ia; alpha-Man-1; alpha-Man-I; alpha-Man-l; alpha-Man-la; alphaMan1a; CG17809; CG18799; CG32682; CG32684; CG42275; DM-GI; dManI; dMas-1; Dmel\CG42275; MA12; Man'ase; MAN-1; ManI; mas-1; mas1
    Old locus tag
    Dmel_CG32682; Dmel_CG32684
    Summary
    Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in determination of adult lifespan; encapsulation of foreign target; and response to anesthetic. Located in endomembrane system. Is expressed in several structures, including adult head; lamina monopolar neuron L5; larval muscle system; presumptive embryonic/larval central nervous system; and synaptic neuropil domain. Orthologous to several human genes including MAN1A1 (mannosidase alpha class 1A member 1) and MAN1A2 (mannosidase alpha class 1A member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha-Man-Ia in Genome Data Viewer
    Location:
    9B5-9B7; 1-31 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10266792..10325958, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10160825..10219991, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Hyperkinetic Neighboring gene antisense RNA:CR43959 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene GIP-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionarily conserved and species-specific glycoproteins in the N-glycoproteomes of diverse insect species. Scheys F, et al. Insect Biochem Mol Biol, 2018 Sep. PMID 29906502
    2. Nuclear Envelope Protein MAN1 Regulates the Drosophila Circadian Clock via Period. Bu B, et al. Neurosci Bull, 2019 Dec. PMID 31230212, Free PMC Article
    3. The alpha-mannosidases: phylogeny and adaptive diversification. Gonzalez DS, et al. Mol Biol Evol, 2000 Feb. PMID 10677852
    4. Male sterile mutant casanova gives clues to mechanisms of sperm-egg interactions in Drosophila melanogaster. Perotti ME, et al. Mol Reprod Dev, 2001 Oct. PMID 11553926
    5. Purification and characterization of the plasma membrane glycosidases of Drosophila melanogaster spermatozoa. Cattaneo F, et al. Insect Biochem Mol Biol, 2002 Aug. PMID 12110300

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Over-expressing per rescued the long period phenotype caused by MAN1 deficiency whereas per mutation had an epistatic effect on MAN1, indicating that MAN1 sets the pace of the clock by targeting per.
      Title: Nuclear Envelope Protein MAN1 Regulates the Drosophila Circadian Clock via Period.
    2. mutations in alpha-1,2-mannosidase I may extend longevity by modulating dietary restriction
      Title: Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c10276449-10267358 mobile_element_type = transposon:roo{}96

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to anesthetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-Mannosidase class I a
    Names
    CG42275-PH
    CG42275-PI
    CG42275-PJ
    CG42275-PK
    CG42275-PL
    CG42275-PM
    CG42275-PN
    CG42275-PO
    CG42275-PP
    alpha 1,2 mannosidase
    alpha mannosidase I
    alpha-1,2-mannosidase I
    alpha-D-mannosidase
    alpha-Man-Ia-PH
    alpha-Man-Ia-PI
    alpha-Man-Ia-PJ
    alpha-Man-Ia-PK
    alpha-Man-Ia-PL
    alpha-Man-Ia-PM
    alpha-Man-Ia-PN
    alpha-Man-Ia-PO
    alpha-Man-Ia-PP
    alpha-mannosidase
    alpha1,2-,mannosidase
    mannosidase 1
    NP_001259402.1
    NP_511105.2
    NP_727407.1
    NP_727408.2
    NP_996395.1
    NP_996396.1
    NP_996397.1
    NP_996398.1
    NP_996399.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10266792..10325958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167223.3 → NP_727407.1  alpha-Mannosidase class I a, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727407.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V480, M9PH54, P53624, P53625, Q9W2W6, Q9W2W7
      Related
      FBpp0289738
      Conserved Domains (1) summary
      cl04955
      Location:198 → 647
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    2. NM_078550.4 → NP_511105.2  alpha-Mannosidase class I a, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511105.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53624
      Related
      FBpp0289739
      Conserved Domains (2) summary
      pfam01532
      Location:183 → 623
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam05223
      Location:78 → 143
      MecA_N; NTF2-like N-terminal transpeptidase domain

    3. NM_206676.3 → NP_996399.1  alpha-Mannosidase class I a, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996399.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V480, M9PH54, P53624, P53625, Q9W2W6, Q9W2W7
      Conserved Domains (1) summary
      cl04955
      Location:198 → 647
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    4. NM_206673.3 → NP_996396.1  alpha-Mannosidase class I a, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V480, M9PH54, P53624, P53625, Q9W2W6, Q9W2W7
      Conserved Domains (1) summary
      cl04955
      Location:198 → 647
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    5. NM_206674.3 → NP_996397.1  alpha-Mannosidase class I a, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996397.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V480, M9PH54, P53624, P53625, Q9W2W6, Q9W2W7
      Conserved Domains (1) summary
      cl04955
      Location:198 → 647
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    6. NM_206675.3 → NP_996398.1  alpha-Mannosidase class I a, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V480, M9PH54, P53624, P53625, Q9W2W6, Q9W2W7
      Conserved Domains (1) summary
      cl04955
      Location:198 → 647
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    7. NM_167224.3 → NP_727408.2  alpha-Mannosidase class I a, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727408.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QD9, Q8IRL4
      Conserved Domains (1) summary
      pfam01532
      Location:224 → 664
      Glyco_hydro_47; Glycosyl hydrolase family 47

    8. NM_206672.3 → NP_996395.1  alpha-Mannosidase class I a, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996395.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V480, M9PH54, P53624, P53625, Q9W2W6, Q9W2W7
      Conserved Domains (1) summary
      cl04955
      Location:198 → 647
      LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

    9. NM_001272473.2 → NP_001259402.1  alpha-Mannosidase class I a, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53624
      Conserved Domains (2) summary
      pfam01532
      Location:183 → 623
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam05223
      Location:78 → 143
      MecA_N; NTF2-like N-terminal transpeptidase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53624.2 P53624
    Q8IRL4 Q8IRL4

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