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    GluRIIA Glutamate receptor IIA [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33788, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GluRIIAprovided by FlyBase
    Official Full Name
    Glutamate receptor IIAprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004620
    Locus tag
    Dmel_CG6992
    See related
    AllianceGenome:FB:FBgn0004620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6992; D-GluRIIA; DGluR-II; dglur-IIA; DGluR-IIA; DGluR2a; dGluRII; DgluRII; dglurIIA; dGluRIIA; DGluRIIa; DGluRIIA; DmelGluRIIA; Dmel\CG6992; Glu-RII; Glu-RIIA; gluIIA; GluR; GluR-IIA; GluR2; GluR2a; GluRII; GluRII-A; gluriia; glurIIA; gluRIIA; GlurIIA; GluRIIa; GluR[[IIa]]
    Summary
    Enables glutamate-gated calcium ion channel activity. Involved in several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and synapse maturation. Located in muscle cell postsynaptic specialization and postsynaptic membrane. Part of ionotropic glutamate receptor complex. Is expressed in several structures, including embryonic/larval neuromuscular junction; larval muscle system; muscle cell; and somatic mesoderm. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GluRIIA in Genome Data Viewer
    Location:
    25E6-25E6; 2-17 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5555072..5558994)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5555072..5558994)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamate receptor IIB Neighboring gene long non-coding RNA:CR44794 Neighboring gene small nuclear RNA U4 at 25F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the genes for excitatory amino acid receptors. Henneberry RC. Bioessays, 1992 Jul. PMID 1359885
    2. Drosophila glutamate receptor RNA expression in embryonic and larval muscle fibers. Currie DA, et al. Dev Dyn, 1995 Jul. PMID 8589428
    3. Target-wide Induction and Synapse Type-Specific Robustness of Presynaptic Homeostasis. Genç Ö, et al. Curr Biol, 2019 Nov 18. PMID 31708391, Free PMC Article
    4. Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation. Li X, et al. Elife, 2018 Apr 5. PMID 29620520, Free PMC Article
    5. The Maintenance of Synaptic Homeostasis at the Drosophila Neuromuscular Junction Is Reversible and Sensitive to High Temperature. Yeates CJ, et al. eNeuro, 2017 Nov-Dec. PMID 29255795, Free PMC Article

    See all (306) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Versatile Endogenous Editing of GluRIIA in Drosophila melanogaster.
      Title: Versatile Endogenous Editing of GluRIIA in Drosophila melanogaster.
    2. Drosophila Mon1 and Rab7 interact to regulate glutamate receptor levels at the neuromuscular junction.
      Title: Drosophila Mon1 and Rab7 interact to regulate glutamate receptor levels at the neuromuscular junction.
    3. PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Abeta42 toxicity.
      Title: PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity.
    4. Postsynaptic cAMP signalling regulates the antagonistic balance of Drosophila glutamate receptor subtypes.
      Title: Postsynaptic cAMP signalling regulates the antagonistic balance of Drosophila glutamate receptor subtypes.
    5. This study reveals a critical role of calpains during development to specifically cleave GluRIIA at synapses and consequently regulate synaptic function
      Title: Calcium-Activated Calpain Specifically Cleaves Glutamate Receptor IIA But Not IIB at the Drosophila Neuromuscular Junction.
    6. dPAK associated with Henji through the Kelch repeats which is the domain essential for Henji localization and function at postsynapses. We propose that Henji acts at postsynapses to restrict both presynaptic bouton growth and postsynaptic GluRIIA abundance by modulating dPAK.
      Title: Dbo/Henji Modulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response.
    7. We propose that DMon1 is part of a presynaptically regulated transsynaptic mechanism that regulates GluRIIA levels at the larval neuromuscular junction.
      Title: A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila.
    8. only Neto-beta restored PAK synaptic accumulation at neto null NMJs. Thus, Neto engages in intracellular interactions that regulate the iGluR subtype composition by preferentially recruiting and/or stabilizing selective receptor subtypes.
      Title: Neto-mediated intracellular interactions shape postsynaptic composition at the Drosophila neuromuscular junction.
    9. Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction
      Title: Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction.
    10. GluR-IIA was rapidly removed from synapses whose activity failed to evoke substantial postsynaptic depolarization.
      Title: Hebbian plasticity guides maturation of glutamate receptor fields in vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate-gated calcium ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate-gated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of synaptic activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ionotropic glutamate receptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in muscle cell postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate receptor IIA
    Names
    CG6992-PI
    GluRIIA-PI
    glutamate IIA receptor
    glutamate receptor
    glutamate receptor subunit IIA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5555072..5558994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078760.3 → NP_523484.2  glutamate receptor IIA [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523484.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24351, Q9VMP4
      Related
      FBpp0078739
      Conserved Domains (4) summary
      cd06382
      Location:33 → 404
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      cd13714
      Location:426 → 796
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:556 → 828
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:46 → 386
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24351 Q24351
    Q9VMP4 Q9VMP4

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