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    Poxm Pox meso [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40990, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Poxmprovided by FlyBase
    Official Full Name
    Pox mesoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003129
    Locus tag
    Dmel_CG9610
    See related
    AllianceGenome:FB:FBgn0003129
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9610; Dmel\CG9610; meso; P29; Pox-m; poxm; POXM
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dendrite morphogenesis and larval somatic muscle development. Located in nucleus. Is expressed in several structures, including embryonic large intestine; embryonic/larval hypodermal muscle cell; esophagus anlage; gut section; and myoblast. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and tooth agenesis. Orthologous to several human genes including PAX1 (paired box 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Poxm in Genome Data Viewer
    Location:
    84F11-84F12; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8319025..8333792, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4144747..4159514, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45215 Neighboring gene Coenzyme Q biosynthesis protein 2 Neighboring gene Copper transporter 1B Neighboring gene Odorant receptor 85a Neighboring gene uncharacterized protein Neighboring gene Cytochrome c oxidase subunit 7A Neighboring gene ADP ribosylation factor-like 2 Neighboring gene Polynucleotide kinase 3'-phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro. Bopp D, et al. EMBO J, 1989 Nov. PMID 2573516, Free PMC Article
    2. Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis. Baumgartner S, et al. Genes Dev, 1987 Dec. PMID 3123319
    3. dpp induces mesodermal gene expression in Drosophila. Staehling-Hampton K, et al. Nature, 1994 Dec 22-29. PMID 7997266
    4. Evolution of functional diversification of the paired box (Pax) DNA-binding domains. Balczarek KA, et al. Mol Biol Evol, 1997 Aug. PMID 9254921
    5. Evolution and role of Pax genes. Noll M. Curr Opin Genet Dev, 1993 Aug. PMID 8241771

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A key role of Pox meso in somatic myogenesis of Drosophila.
      Title: A key role of Pox meso in somatic myogenesis of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pox meso
    Names
    CG9610-PC
    Pox-meso
    Poxm-PC
    paired box mesodermal
    paired box-meso

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8319025..8333792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043222.3 → NP_001036687.1  Pox meso [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4K7U1, P23757, Q1RL17, Q9VHS5
      Conserved Domains (1) summary
      smart00351
      Location:10 → 133
      PAX; Paired Box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23757.3 P23757

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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