Grd Glycine receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Grdprovided by FlyBase
Official Full Name: Glycine receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0001134
Locus tag: Dmel_CG7446
See related: AllianceGenome:FB:FBgn0001134
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7446; CT22917; Dmel\CG7446; DmGABA(GRD); GRD
Summary: Enables GABA-A receptor activity; GABA-gated chloride ion channel activity; and monoatomic cation channel activity. Involved in several processes, including glycinergic synaptic transmission; negative regulation of neuronal action potential; and regulation of circadian rhythm. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in bipolar disorder; depressive disorder; epilepsy (multiple); and multiple sclerosis. Orthologous to several human genes including GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1); GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3); and GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 75A2-75A4; 3-45 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (17823333..17839767)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (17816433..17832867)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 17834612-17834730 mobile_element_type = transposon:X{}4493

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-gated chloride ion channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glycine-gated ion channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycine-gated chloride ion channel activity	TAS Traceable Author Statement more info	PubMed
enables ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glycinergic	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: glycine receptor

Names: CG7446-PA; GABA and glycine-like receptor of drosophila; GABA-and-glycine-receptor-like-subunit-of-Drosophila; GABA/Glycine-gated chloride channel-like; Grd-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

17823333..17839767

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079407.3 → NP_524131.1 glycine receptor [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524131.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24352, Q9TX50, Q9VVL3

UniProtKB/TrEMBL

F3YDK8

Related

FBpp0074905

Conserved Domains (3) summary

TIGR00860
Location:111 → 670

LIC; Cation transporter family protein

pfam02931
Location:110 → 326

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:398 → 667

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region