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    Tgt tRNA-guanine transglycosylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33307, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tgtprovided by FlyBase
    Official Full Name
    tRNA-guanine transglycosylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031321
    Locus tag
    Dmel_CG4947
    See related
    AllianceGenome:FB:FBgn0031321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4947; Dmel\CG4947; tgt; TGT
    Summary
    Predicted to enable tRNA-guanosine(34) queuine transglycosylase activity. Predicted to be involved in tRNA-guanine transglycosylation. Predicted to be part of tRNA-guanine transglycosylase complex. Is expressed in organism. Orthologous to human QTRT1 (queuine tRNA-ribosyltransferase catalytic subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tgt in Genome Data Viewer
    Location:
    21F2-21F2; 2-2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1184065..1185698)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1184065..1185698)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. On the possible role of tRNA base modifications in the evolution of codon usage: queuosine and Drosophila. Chiari Y, et al. J Mol Evol, 2010 Apr. PMID 20333371
    2. A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus. Zaborske JM, et al. PLoS Biol, 2014 Dec. PMID 25489848, Free PMC Article
    3. Evidence for large domains of similarly expressed genes in the Drosophila genome. Spellman PT, et al. J Biol, 2002. PMID 12144710, Free PMC Article
    4. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Breznak SM, et al. Sci Adv, 2023 Jun 23. PMID 37343092, Free PMC Article
    5. Photoperiod-Dependent Expression of MicroRNA in Drosophila. Pegoraro M, et al. Int J Mol Sci, 2022 Apr 29. PMID 35563325, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tRNA-guanosine(34) queuine transglycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA-guanine transglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA-guanine transglycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-guanine transglycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of tRNA-guanine transglycosylase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-guanine transglycosylase
    Names
    CG4947-PA
    Tgt-PA
    NP_608585.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1184065..1185698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134741.3 → NP_608585.1  tRNA-guanine transglycosylase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VPY8
      Related
      FBpp0077636
      Conserved Domains (2) summary
      COG0343
      Location:17 → 375
      Tgt; Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]
      cl19224
      Location:7 → 372
      TGT; Queuine tRNA-ribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPY8.1 Q9VPY8

    Gene LinkOut

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