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    Sodh2 Sorbitol dehydrogenase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sodh2provided by FlyBase
    Official Full Name
    Sorbitol dehydrogenase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0022359
    Locus tag
    Dmel_CG4649
    See related
    AllianceGenome:FB:FBgn0022359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4649; Dmel\CG4649; DM_7299382; Sdh; Sdh-2; Sodh-2; SODH-2
    Summary
    Enables L-iditol 2-dehydrogenase (NAD+) activity. Involved in fructose biosynthetic process and sorbitol catabolic process. Predicted to be active in cytosol. Is expressed in adult head; amnioserosa; embryonic/larval midgut; organism; and yolk nucleus. Used to study autosomal recessive distal hereditary motor neuronopathy 8. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sodh2 in Genome Data Viewer
    Location:
    86C7-86C7; 3-50 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10876384..10878257)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6702106..6703979)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Formaldehyde dehydrogenase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45195 Neighboring gene uncharacterized protein Neighboring gene Thiamine pyrophosphate carrier protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sorbitol reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration in sorbitol dehydrogenase deficiency. Zhu Y, et al. JCI Insight, 2023 May 22. PMID 37014713, Free PMC Article
    2. Sorbitol dehydrogenase of Drosophila. Gene, protein, and expression data show a two-gene system. Luque T, et al. J Biol Chem, 1998 Dec 18. PMID 9852094
    3. Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes. Cortese A, et al. Nat Genet, 2020 May. PMID 32367058, Free PMC Article
    4. Drosophila TRF2 is a preferential core promoter regulator. Kedmi A, et al. Genes Dev, 2014 Oct 1. PMID 25223897, Free PMC Article
    5. The polyol pathway is an evolutionarily conserved system for sensing glucose uptake. Sano H, et al. PLoS Biol, 2022 Jun. PMID 35687590, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-iditol 2-dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-iditol 2-dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-iditol 2-dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-iditol 2-dehydrogenase (NAD+) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sorbitol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sorbitol catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sorbitol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sorbitol dehydrogenase 2
    Names
    CG4649-PA
    Sodh2-PA
    sorbitol dehydrogenase
    sorbitol dehydrogenase-2
    NP_524311.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10876384..10878257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079587.3 → NP_524311.1  sorbitol dehydrogenase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524311.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96299, Q960H1
      Related
      FBpp0081800
      Conserved Domains (2) summary
      cd05285
      Location:8 → 349
      sorbitol_DH; Sorbitol dehydrogenase
      PLN02702
      Location:4 → 346
      PLN02702; L-idonate 5-dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96299 O96299

    Gene LinkOut

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