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    Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303547, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ezh1provided by RGD
    Official Full Name
    enhancer of zeste 1 polycomb repressive complex 2 subunitprovided by RGD
    Primary source
    RGD:1305028
    See related
    EnsemblRapid:ENSRNOG00000020336 AllianceGenome:RGD:1305028
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables chromatin binding activity. Involved in hippocampus development and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromosome, telomeric region; heterochromatin; and nucleoplasm. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 177.3), Lung (RPKM 163.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ezh1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86626307..86662257, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86126023..86162001, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89104026..89139978, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H3 Neighboring gene contactin associated protein 1 Neighboring gene C-C motif chemokine receptor 10 Neighboring gene uncharacterized LOC134480876 Neighboring gene uncharacterized LOC120095184 Neighboring gene receptor activity modifying protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration. Bae WK, et al. FASEB J, 2015 May. PMID 25477280, Free PMC Article
    2. Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Henriquez B, et al. Mol Cell Neurosci, 2013 Nov. PMID 23932971
    3. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Margueron R, et al. Mol Cell, 2008 Nov 21. PMID 19026781, Free PMC Article
    4. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, et al. Trends Biochem Sci, 2013 Dec. PMID 24148750, Free PMC Article
    5. Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. van Lohuizen M, et al. Mol Cell Biol, 1998 Jun. PMID 9584197, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. knock-down of Ezh1 reduces PSD-95 transcription in developing hippocampal neurons
      Title: Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K27 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K27 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K27 trimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in facultative heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hepatocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hippocampus development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within liver regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to tetrachloromethane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in subtelomeric heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase EZH1
    Names
    enhancer of zeste homolog 1
    NP_001100521.1
    XP_006247380.1
    XP_006247381.1
    XP_008766274.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107051.1 → NP_001100521.1  histone-lysine N-methyltransferase EZH1

      See identical proteins and their annotated locations for NP_001100521.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HJ95, F1LZH3
      Related
      ENSRNOP00000027640.7, ENSRNOT00000027640.8
      Conserved Domains (5) summary
      COG2940
      Location:463 → 727
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:433 → 474
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cd19217
      Location:608 → 743
      SET_EZH1; SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins
      pfam11616
      Location:39 → 68
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:159 → 262
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86626307..86662257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247318.5 → XP_006247380.1  histone-lysine N-methyltransferase EZH1 isoform X1

      See identical proteins and their annotated locations for XP_006247380.1

      UniProtKB/TrEMBL
      F1LZH3
      Conserved Domains (5) summary
      COG2940
      Location:463 → 727
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:433 → 474
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cd19217
      Location:608 → 743
      SET_EZH1; SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins
      pfam11616
      Location:39 → 68
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:159 → 262
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

    2. XM_008768052.4 → XP_008766274.1  histone-lysine N-methyltransferase EZH1 isoform X1

      See identical proteins and their annotated locations for XP_008766274.1

      UniProtKB/TrEMBL
      F1LZH3
      Conserved Domains (5) summary
      COG2940
      Location:463 → 727
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:433 → 474
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cd19217
      Location:608 → 743
      SET_EZH1; SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins
      pfam11616
      Location:39 → 68
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:159 → 262
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

    3. XM_006247319.4 → XP_006247381.1  histone-lysine N-methyltransferase EZH1 isoform X1

      See identical proteins and their annotated locations for XP_006247381.1

      UniProtKB/TrEMBL
      F1LZH3
      Conserved Domains (5) summary
      COG2940
      Location:463 → 727
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00167
      Location:433 → 474
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cd19217
      Location:608 → 743
      SET_EZH1; SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins
      pfam11616
      Location:39 → 68
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:159 → 262
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    Nucleotide Protein Strain
    Heading Accession and Version

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