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    Larp1 La ribonucleoprotein 1, translational regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303158, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Larp1provided by RGD
    Official Full Name
    La ribonucleoprotein 1, translational regulatorprovided by RGD
    Primary source
    RGD:1306683
    See related
    EnsemblRapid:ENSRNOG00000031544 AllianceGenome:RGD:1306683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306683
    Summary
    Predicted to enable eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Predicted to be involved in several processes, including TORC1 signaling; cellular response to rapamycin; and post-transcriptional regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be part of TORC1 complex. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human LARP1 (La ribonucleoprotein 1, translational regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 308.6), Muscle (RPKM 248.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Larp1 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42691833..42746816)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (42191378..42246361)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43435738..43501186)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene bolA-like protein 2 Neighboring gene uncharacterized LOC134480691 Neighboring gene ATP synthase membrane subunit K like 1 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene uncharacterized LOC134480692

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes. Gentilella A, et al. Mol Cell, 2017 Jul 6. PMID 28673543, Free PMC Article
    2. LARP1 specifically recognizes the 3' terminus of poly(A) mRNA. Aoki K, et al. FEBS Lett, 2013 Jul 11. PMID 23711370
    3. The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence. Lahr RM, et al. Nucleic Acids Res, 2015 Sep 18. PMID 26206669, Free PMC Article
    4. Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation. Tcherkezian J, et al. Genes Dev, 2014 Feb 15. PMID 24532714, Free PMC Article
    5. La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region. Philippe L, et al. Nucleic Acids Res, 2018 Feb 16. PMID 29244122, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to rapamycin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    la-related protein 1
    Names
    La ribonucleoprotein domain family, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427639.2 → NP_001414568.1  la-related protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6GJC3
      Related
      ENSRNOP00000091072.2, ENSRNOT00000113107.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      42691833..42746816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087207.2 → XP_038943135.1  la-related protein 1 isoform X1

      UniProtKB/TrEMBL
      F1M062
      Conserved Domains (3) summary
      smart00684
      Location:795 → 833
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      COG5193
      Location:259 → 425
      LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
      cl02755
      Location:271 → 343
      LAM; LA motif RNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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