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    Cptp ceramide-1-phosphate transfer protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313771, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cptpprovided by RGD
    Official Full Name
    ceramide-1-phosphate transfer proteinprovided by RGD
    Primary source
    RGD:1359656
    See related
    EnsemblRapid:ENSRNOG00000022455 AllianceGenome:RGD:1359656
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gltpd1
    Summary
    Predicted to enable ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Predicted to be involved in several processes, including ceramide 1-phosphate transport; negative regulation of NLRP3 inflammasome complex assembly; and negative regulation of interleukin-1 beta production. Predicted to be located in Golgi apparatus; bounding membrane of organelle; and plasma membrane. Predicted to be active in cytosol. Orthologous to human CPTP (ceramide-1-phosphate transfer protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 81.3), Testes (RPKM 74.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cptp in Genome Data Viewer
    Location:
    5q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171757181..171761271, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166474947..166479103, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173314219..173318384, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene matrix remodeling associated 8 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste 1 receptor member 3 Neighboring gene integrator complex subunit 11 Neighboring gene pseudouridine synthase like 1 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation. Mishra SK, et al. Autophagy, 2018. PMID 29164996, Free PMC Article
    2. Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Simanshu DK, et al. Nature, 2013 Aug 22. PMID 23863933, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94339

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide 1-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide 1-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ceramide 1-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ceramide 1-phosphate transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide 1-phosphate transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ceramide 1-phosphate transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide 1-phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ceramide 1-phosphate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ceramide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in glycolipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermembrane lipid transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of NLRP3 inflammasome complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ceramide-1-phosphate transfer protein
    Names
    glycolipid transfer protein domain containing 1
    glycolipid transfer protein domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007703.1 → NP_001007704.1  ceramide-1-phosphate transfer protein

      See identical proteins and their annotated locations for NP_001007704.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083599
      UniProtKB/Swiss-Prot
      Q5XIS2
      UniProtKB/TrEMBL
      A6IUT7
      Related
      ENSRNOP00000034006.3, ENSRNOT00000039117.5
      Conserved Domains (1) summary
      pfam08718
      Location:30 → 175
      GLTP; Glycolipid transfer protein (GLTP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171757181..171761271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110121.2 → XP_038966049.1  ceramide-1-phosphate transfer protein isoform X2

      Conserved Domains (1) summary
      pfam08718
      Location:2 → 112
      GLTP; Glycolipid transfer protein (GLTP)

    2. XM_006239576.5 → XP_006239638.1  ceramide-1-phosphate transfer protein isoform X1

      See identical proteins and their annotated locations for XP_006239638.1

      UniProtKB/Swiss-Prot
      Q5XIS2
      UniProtKB/TrEMBL
      A6IUT7
      Conserved Domains (1) summary
      pfam08718
      Location:30 → 175
      GLTP; Glycolipid transfer protein (GLTP)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIS2.1 GenPept UniProtKB/Swiss-Prot:Q5XIS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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