Arhgap28 Rho GTPase activating protein 28 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap28provided by RGD
Official Full Name: Rho GTPase activating protein 28provided by RGD
Primary source: RGD:1559882
See related: EnsemblRapid:ENSRNOG00000017065 AllianceGenome:RGD:1559882
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559882
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of stress fiber assembly; regulation of actin filament polymerization; and regulation of small GTPase mediated signal transduction. Predicted to be located in cell junction and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in allergic disease. Orthologous to human ARHGAP28 (Rho GTPase activating protein 28). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 72.8), Lung (RPKM 46.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q38

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (115277849..115444789, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (107832584..107998030, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (116057229..116222440, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE120317 (e-PCR)
- UniSTS:247301

D9Got141 (e-PCR)
- UniSTS:115768

AA891588 (e-PCR)
- UniSTS:249940

BF397576 (e-PCR)
- UniSTS:246235

D9Rat103 (e-PCR), detects polymorphism
- UniSTS:228317

AB072742 (e-PCR)
- UniSTS:480232

d9mit8 (e-PCR)
- UniSTS:120565

D9Mgh7 (e-PCR)
- UniSTS:239868

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of small GTPase mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191815.1 → NP_001178744.1 rho GTPase-activating protein 28

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

F1M332

Related

ENSRNOP00000063588.5, ENSRNOT00000067900.5

Conserved Domains (1) summary

cd04391
Location:378 → 589

RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

115277849..115444789 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083430.2 → XP_038939358.1 rho GTPase-activating protein 28 isoform X1

Conserved Domains (1) summary

cd04391
Location:378 → 588

RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
XM_006245626.5 → XP_006245688.1 rho GTPase-activating protein 28 isoform X2

UniProtKB/TrEMBL

A0A0G2JWW2

Related

ENSRNOP00000070038.2, ENSRNOT00000090111.3

Conserved Domains (1) summary

cd04391
Location:360 → 571

RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...